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#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D.

If you prevent aging and age-related disease, you’re going to compress morbidity, too.” — Nir Barzilai

Science of Aging

#35 – Nir Barzilai, M.D.: How to tame aging

“I think the prevention of aging is really a good place to be. . .and I think life is going to be very different in the next decade with our advances.” —Nir Barzilai

Science of Aging

#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19

“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick

Science of Aging

About TAME: A Metformin Anti-Aging Clinical Trial with Nir Barzilai, M.D.

This video clip is from episode #204 – Centenarians, metformin, and longevity with Nir Barzilai, M.D., originally released on April…

Insulin Resistance

Qualys #165 – Attempting to define insulin resistance with Nir Barzilai, M.D.

This episode of The Qualys is from podcast #33 — Nir Barzilai, M.D.: How to tame aging — which was originally released on January 7, 2019.


Qualys #241 – The genetic gift of centenarians

This episode of The Qualys is from podcast #35, Nir Barzilai, M.D.: How to tame aging, which was originally released on January 7, 2019.


Lessons from centenarians: why prevention of chronic disease is critical

To me, the takeaway for us, as physicians or people who want to have an extra five years of life or 10 years of life… is nothing matters more than prevention of chronic disease. And by the way, you don’t get to prevent it once you have your heart attack. Secondary prevention is not prevention.” – Peter Attia, M.D.

Science of Aging

#175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

“I don’t think I will ever understand aging fully. And I don’t think the field will. … But I also believe that we don’t have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein

Science of Aging

#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin

“It’s really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it’s difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein

Science of Aging

#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?

“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha

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