Learn more about Peter Attia’s digital program
#41 – Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights
“You have this unique population of [type 1 diabetics] where you can see the insulin that goes into them, and you can see it’s direct impact on weight gain. . . and they’re at risk for cardiovascular illness. And to me that just says that there’s something about the Standard American Diet that’s making us sick. And ultimately we will all be at risk for cardiovascular disease.” —Jake Kushner
#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins
“It is worth noting, and this is a very important question, that it does not appear that the effect of statins on insulin resistance is a function of lipids being lowered.” —Peter Attia
#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers
“This paper basically addresses how our beliefs about the drugs we take impacts how they affect us at a real level, not just at a subjective level, but at a biological level.” —Andrew Huberman
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
#246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent
“The thing that concerns me the most with these drugs. . .is this drive towards sarcopenia.” —Peter Attia
#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM
“One of the most humbling things about this job is when I meet the children or the adult patients who has had this device change their life . . . it’s really why we come to work every day, what keeps us going.” —Kevin Sayer
#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
“My perspective has shifted as any scientist that’s following data should… When new data comes out, you have to reassess things.” —Rhonda Patrick
#251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more
“The bottom line here is the earlier you were diagnosed with type 2 diabetes, the higher your risk of dementia.” —Peter Attia
#201 – Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)
“You can accomplish very important mitochondrial adaptations and very important metabolic adaptations by exercising one hour.” —Iñigo San-Millán