Mental models

The Epidemic on the Road

Motor vehicle accidents are a common yet often overlooked cause of death – and the numbers are rising.

Understanding science

Small steps toward improving research reliability

Unfortunately, scientific publishing is riddled with myriad problems, many of which likely can’t be solved without completely rethinking current processes and the underlying research culture. However, there are still small, short-term changes that are relatively easy to implement and can yield meaningful improvements in research integrity.

Cognitive Health & Neurodegenerative Disease

Adding context to the Alzheimer’s disease research fraud charges

This past July, a news article published in Science sent shockwaves through the scientific community when it reported that one of the most influential and frequently-cited publications in Alzheimer’s disease (AD) research was evidently based on fraud.

 

Cardiovascular Disease

Heart Disease: Labs & Diagnostic Tests

This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18,…

Mental & Emotional Health

Prioritizing “real friends” over “deal friends”

According to a May 2021 survey, Americans report having fewer close friendships than they did 30 years ago. But according to a recent conversation I had with author and social scientist Arthur Brooks, friendship is one of the key factors in finding and maintaining happiness as we age. 

 

Nutritional Biochemistry

Different effects of fat- vs. carbohydrate-restriction on neural reward signaling

“A calorie is a calorie” seems like a simple and obvious statement. But do different macronutrients vary in their ability to drive obesity? A recent study by Dr. Kevin Hall and colleagues provides new clues – and likely new fodder for debate.

Insulin Resistance

The five main tools for managing blood glucose numbers

This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on…

Medications, Supplements & Other Treatments

Vitamin D(éjà vu): new study, same old problems

For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D, and if it doesn’t, then the treatment and placebo groups are effectively identical. So did the researchers achieve a difference in vitamin D levels over the course of the study?

Preventing Chronic Disease

First Case of Human PCSK9 Gene-Editing

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

Strength & Muscle Mass

Avoiding Injury Part II: Grip Strength

Not enough can be said about the importance of grip strength as you age. It’s one of the strongest physical associations with longer life.

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