Medications, Supplements & Other Treatments

Metformin and exercise – déjà vu all over again?

Metformin blunts muscle hypertrophy in response to progressive resistance training

Understanding science

Am I fooling myself?

This story serves to remind me that we are not wired to think scientifically. Full stop. It is the quintessential human flaw. But scientific thinking is a skill to be practiced and improved upon.

Science of Aging

Did a recent study show we can reverse aging?

I dig a little deeper into the recent study that suggests (to some) the answer is yes.

Medications, Supplements & Other Treatments

Hormone therapy and breast cancer?

There are not many topics in clinical medicine more polarizing than hormone replacement therapy (HRT) for women suffering from menopausal…

Science of Aging

Can you reverse your biological age?

I realize it may seem like Groundhog Day for you to see more prose from me about how to think about studies rather than the tactical bits we think we can immediately extract and employ from them. Just remember, it’s better to learn how to fish than to be given … you get it.

Fasting

Alternate Day Fasting

I’m left bewildered: there are more questions than answers in most scientific pursuits, but I want to stress the point here that these aren’t rhetorical questions.

Fasting

Can you maintain muscle during fasting?

But in the short-term (at least up to a week for most people), I believe you can maintain muscle mass while fasting, particularly if you’re resistance training.

Fasting

Can you preserve lean body mass during “semi-starvation?”

All of this is very interesting, but what I find much more interesting in this study is that the placebo group did not lose any substantive LBM, while losing about the same amount of fat (10 lb) as the testosterone group, despite the severe CR/energy-deficit.

Understanding science

What can you prove?

If that weren’t enough to set me off, consider the overall weakness of this study, and the choice of the word “proven” borders on journalistic manslaughter.

Mental & Emotional Health

What if you never felt pain or anxiety?

That just floored me. Is there a connection between physical and emotional pain tolerance?

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