Understanding science

Research Worth Sharing, December 2023 Edition

MDMA for PTSD, the HALL aging database, peanut immunotherapy, blood pressure cuff sizes and accuracy, and the effects of swearing on strength

Nutritional Biochemistry

Why is it so difficult to determine how nutrition impacts dementia risk?

When it comes to nutrition research, neither observational nor interventional studies have been able to tell the full story. A report by the Nutrition for Dementia Prevention Working Group offers ideas for improving both.

Cognitive Health & Neurodegenerative Disease

The MIND diet on trial: can diet choices impact cognitive health?

The results were lackluster, but a closer look leaves room for other explanations

Preventing Chronic Disease

Reassessing the relationship between alcohol intake and cardiovascular disease risk

Mendelian randomization offers clearer insights than epidemiology or randomized trials to date

Science of Aging

“Biological” clocks: a peek into the future or a haphazard guess of mortality?

Potential uses for the epigenetics of aging and why I don’t put much stock in epigenetics-based aging clocks at present

Medications, Supplements & Other Treatments

Do GLP-1 receptor agonists improve cardiovascular health independently of weight loss?

A new trial has reported that the GLP-1 receptor agonist semaglutide reduces risk of cardiovascular events in patients with obesity – but that’s not the question we ought to be asking.

Preventing Chronic Disease

How does APOE status impact the relationship between obesity and dementia risk?

Obesity has been reported by some to increase risk of dementia, while other studies have reported that obesity is protective against dementia. Might the effects of APOE genotype help to explain the discrepancy?

Preventing Chronic Disease

Is the frequency of menopausal symptoms an early barometer for later-in-life brain health?

More than “bothersome”: Frequent menopausal hot flashes during sleep are associated with greater white matter hyperintensity volume

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