Science of Aging

Learn more about the biology of aging, centenarians, rapamycin, mTOR, ‘anti-aging’ drugs, interventions that target the aging process, and more.

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

It’s really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein

#214 – AMA #37: Bone health—everything you need to know

The bones are mechanical sensory entities that are going to remodel in proportion to how much mechanical stress they’re under…so lifting heavy stuff matters.” —Peter Attia

Why sleep is the best insurance policy for lifespan and healthspan

This video clip is from episode #58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping…

The difference between a ‘clean’ drug and a ‘dirty’ drug

This clip is from episode #207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin, originally released on May…

#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.

People don’t just die from disease, they die from the care itself.” —Marty Makary

Are there “biomarkers” for aging?

This clip is from “Ask Me Anything” (AMA) episode #35, originally released on May 16, 2022. If you’re a member,…

#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin

“It’s really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it’s difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein

The challenges of defining aging with Matt Kaeberlein, Ph.D.

This video clip is from episode #175 – The biology of aging, rapamycin, and other interventions that target the aging…

Potential Risks of NAD Supplements with Iñigo San-Millán, Ph.D.

This video clip is from episode #201 – Deep dive back into Zone 2 with Iñigo San-Millán, Ph.D. (Pt. 2),…

About TAME: A Metformin Anti-Aging Clinical Trial with Nir Barzilai, M.D.

This video clip is from episode #204 – Centenarians, metformin, and longevity with Nir Barzilai, M.D., originally released on April…

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