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#68 – Marty Makary, M.D.: The US healthcare system—why it’s broken, steps to fix it, and how to protect yourself
“We’re trying to empower people in the United States to say we need a competent and fair pricing system.” — Marty Makary
#67 – AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more
“If you are genetically blessed to become a centenarian, the gift you got is that you have genes that delay your receipt of chronic disease by what appears to be about 20 years.” — Peter Attia
#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM
“One of the most humbling things about this job is when I meet the children or the adult patients who has had this device change their life . . . it’s really why we come to work every day, what keeps us going.” —Kevin Sayer
Targeting aging
Given that “TOR” is literally “Target of Rapamycin,” it’s no surprise that rapamycin may increase longevity.
#50 – AMA #5: calcium scores, Centenarian Decathlon™, exercise, muscle glycogen, keto, and more
“We’re really talking a completely new model, which is actually forcing your way to become a centenarian rather than just sort of gliding your way into it and therefore, I think it’s going to require much more deliberate attention around what your mind and body are doing at that point and time.” — Peter Attia
#35 – Nir Barzilai, M.D.: How to tame aging
“I think the prevention of aging is really a good place to be. . .and I think life is going to be very different in the next decade with our advances.” —Nir Barzilai
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
“This is a lesson for anyone who’s listening who thinks that getting to somewhere like this is easy. You have to be massively determined, you have to have grit, and I just wouldn’t give up because there’s nothing else I want to do in my life.” —David Sinclair
Easter Island, inflammation, and ask me anything
The implications of the story are frightening, but kudos to the correspondent and photographer that put this story together.
Boston: Pearl Jam, Seyfried, Sinclair, and more
Definitely shared the sentiment with Eddie Vedder when he said he didn’t remember Boston being so tropical.