Category

Insulin Resistance

Insulin resistance (IR) is a topic that’s been of paramount interest in medical research for nearly a century. Insulin is a pancreatic hormone which plays key roles in the metabolism of carbohydrates and fats.

What is Insulin Resistance? When tissues become less responsive to the effects of insulin, the pancreas must produce more and more insulin to maintain glucose homeostasis; this state is the definition of insulin resistance. IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions.

How can we prevent IR from developing, and can it be reversed? IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions, ranging from atherosclerotic cardiovascular disease to Alzheimer’s disease to cancer to fatty liver disease. These threats underscore the critical importance of IR prevention and mitigation (or even reversal) as part of the effort toward extending lifespan and healthspan.

Below is a compilation of podcasts, clips, and articles focused on insulin resistance, what it means, and strategies for prevention and treatment.

Peter Attia on How Insulin Resistance Manifests in the Muscle

“If you’re in the business of wanting to live the healthiest life you can live, which means longer and better, you’ve got to be insulin sensitive, full stop.” — Peter Attia

#194 – How fructose drives metabolic disease | Rick Johnson, M.D.

Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson

#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions

Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia

Does NMN improve metabolic health in humans?

Thoughts on the first efficacy trial recently published

#149 – AMA #20: Simplifying the complexities of insulin resistance: how it’s measured, how it manifests in the muscle and liver, and what we can do about it

“If you’re in the business of wanting to live the healthiest life you can live, which means longer and better, you’ve got to be insulin sensitive, full stop.” — Peter Attia

#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman

#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico

“Skeletal muscles are the greatest reservoir that you have for glucose disposal.” —Peter Attia

#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley

#88 – Paul Grewal, M.D.: Treating metabolic disease and strategies for long-term health

“You could say our food supply has changed more in the last 100 years than it has in the last 10,000.” — Paul Grewal

#87 – Rick Johnson, M.D.: Metabolic Effects of Fructose

“Fructose turns out to be used by animals as a mechanism to store fat.” — Rick Johnson

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