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Insulin Resistance

Insulin resistance (IR) is a topic that’s been of paramount interest in medical research for nearly a century. Insulin is a pancreatic hormone which plays key roles in the metabolism of carbohydrates and fats.

What is Insulin Resistance? When tissues become less responsive to the effects of insulin, the pancreas must produce more and more insulin to maintain glucose homeostasis; this state is the definition of insulin resistance. IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions.

How can we prevent IR from developing, and can it be reversed? IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions, ranging from atherosclerotic cardiovascular disease to Alzheimer’s disease to cancer to fatty liver disease. These threats underscore the critical importance of IR prevention and mitigation (or even reversal) as part of the effort toward extending lifespan and healthspan.

Below is a compilation of podcasts, clips, and articles focused on insulin resistance, what it means, and strategies for prevention and treatment.

Peter Attia on the role of exercise in mitigating and reversing insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #20, originally released on February 15, 2021. If you’re a member, you…

Qualys #168 – Sleep and insulin resistance with Matthew Walker, Ph.D.

This episode of The Qualys is from podcast #33 — Matthew Walker, Ph.D., on sleep Part III — which was originally released on April 15, 2019.

Qualys #166 – Theories on the origins and evolutionary reasons for insulin resistance

This episode of The Qualys is from podcast #69 — Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease — which was originally released on September 2, 2019.

Qualys #261 – Insulin: The amazing story of its discovery, its effect on cellular metabolism and IGF-1, and why it’s so expensive

This episode of The Qualys is from podcast #69 — Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights — which was originally released on February 18, 2019.

Qualys #165 – Attempting to define insulin resistance with Nir Barzilai, M.D.

This episode of The Qualys is from podcast #33 — Nir Barzilai, M.D.: How to tame aging — which was originally released on January 7, 2019.

Qualys #101 – What the hell does insulin resistance actually mean?

This episode of The Qualys is from podcast #33 — Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin — which was originally released on December 17, 2018.

Peter Attia on How Insulin Resistance Manifests in the Muscle

“If you’re in the business of wanting to live the healthiest life you can live, which means longer and better, you’ve got to be insulin sensitive, full stop.” — Peter Attia

#194 – How fructose drives metabolic disease | Rick Johnson, M.D.

“Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson

#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions

“Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia

Does NMN improve metabolic health in humans?

Thoughts on the first efficacy trial recently published

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