Metabolic disease

One way to think about metabolic disease is as a disorder in fuel processing. Whether we’re talking about hyperinsulinemia or type 2 diabetes, the fundamental problem is that the body is not doing a good job storing and accessing fuel.

I think of the three most deadly chronic diseasesheart disease, cancer, and dementia — as pillars all resting on the foundation of metabolic disease. While complications from metabolic disease often do not directly lead to death, the indirect cost is staggering. Each of the other major pillars of chronic disease is exacerbated and amplified by metabolic dysregulation.

Metabolic disease typically exists on a continuum — progressing from hyperinsulinemia, to insulin resistance, to non-alcoholic fatty liver disease, all the way to type 2 diabetes — and tends to cluster with five signs which make up the diagnostic criteria for Metabolic Syndrome, including: high blood pressure, elevated triglycerides, elevated blood glucose, truncal obesity, and low HDL-cholesterol.

The following is a collection of content that dives deeper into the topic of metabolic health, discussing specific strategies for prevention and treatment.

#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

“I’ve always felt that it was really somehow an enormous opportunity and a gift to be able to pursue this down to the level that I’ve been able to do in the past 30 years.” —Rudy Leibel

#30 – Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

“The standard of care should never have been written in granite. It should be flexible. If you have something else that comes along that might be better, you’d think there would be enthusiasm.” —Tom Seyfried

When does heart disease begin (and what this tells us about prevention)?

Before I get into this post I want to lay a few things out.

The War on Cancer

How are we faring in the War on Cancer?

Is a Mediterranean diet best for preventing heart disease?

This week an article titled Primary Prevention of Cardiovascular Disease with a Mediterranean Diet was featured in the New England…

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