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Cognitive Health & Neurodegenerative Disease

Patients often tell me they would like to live as long as they reasonably can, provided they do not suffer cognitive decline. More often than not, people care less about how long they live and more about how well they live, specifically as it pertains to their brain.

Anyone who has seen a relative suffer from a neurodegenerative disease – such as dementia or Alzheimer’s disease – can no doubt relate to the debilitating nature of these conditions. Unlike heart disease and cancer, which kill directly, the fatal impact of neurodegenerative diseases is often indirect.

While much is still unknown, data suggest that there are indeed things that can be done to ward off one’s risk of developing a neurodegenerative disease. Aside from genetics, the next most common risk factor we see is vascular disease.

The adage “what’s good for the heart is good for the brain” rings true here. Meaning, the factors that increase your risk for atherosclerosis – such as high blood pressure, smoking, and elevated apoB – also increase the risk of dementia.

Below is a collection of past articles and podcasts exploring such tactics. My hope is that this content can serve as helpful resources to dive deeper into this topic as well as support your ongoing longevity journey.

Non-caffeine components of coffee and their effects on neurodegenerative diseases

Coffee consumption is associated with reduced risk of Alzheimer’s disease and other neurodegenerative processes, but the effect may be more than a matter of caffeine.

#236 ‒ Neurodegenerative disease: pathology, screening, and prevention | Kellyann Niotis, M.D.

“When you think of brain health, it’s not just the cognitive piece, but it’s the movement piece too.” ‒ Kellyann Niotis

reduce alzheimers risk

Can an annual flu vaccine reduce your risk of Alzheimer’s disease?

A recent retrospective study suggests that flu vaccines reduce risk of Alzheimer’s disease, but the study raises as many questions as it answers.

Adding context to the Alzheimer’s disease research fraud charges

This past July, a news article published in Science sent shockwaves through the scientific community when it reported that one of the most influential and frequently-cited publications in Alzheimer’s disease (AD) research was evidently based on fraud.

 

Alzheimer’s disease — what labs can tell you about your risk

This clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity,…

Why does Alzheimer’s disease affect more women than men?

This clip is from episode #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives,…

The connection between sleep and Alzheimer’s disease

This audio clip is from episode #47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of…

Does exercise reduce the risk of Alzheimer’s disease?

This clip is from episode #18 – Richard Isaacson, M.D.: Alzheimer’s prevention, originally release on October 1, 2018.  

Peter on Alzheimer’s disease prevention and the latest on APOE4

This clip is from episode #202, Peter on nutrition, disease prevention, sleep, and more, originally released on April 11, 2022….

#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

“I really think that in 10 years we’re going to basically be using designer-based immunotherapies to eradicate most solid organ metastatic cancers.” —Peter Attia

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