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Cognitive Health & Neurodegenerative Disease

Patients often tell me they would like to live as long as they reasonably can, provided they do not suffer cognitive decline. More often than not, people care less about how long they live and more about how well they live, specifically as it pertains to their brain.

Anyone who has seen a relative suffer from a neurodegenerative disease – such as dementia or Alzheimer’s disease – can no doubt relate to the debilitating nature of these conditions. Unlike heart disease and cancer, which kill directly, the fatal impact of neurodegenerative diseases is often indirect.

While much is still unknown, data suggest that there are indeed things that can be done to ward off one’s risk of developing a neurodegenerative disease. Aside from genetics, the next most common risk factor we see is vascular disease.

The adage “what’s good for the heart is good for the brain” rings true here. Meaning, the factors that increase your risk for atherosclerosis – such as high blood pressure, smoking, and elevated apoB – also increase the risk of dementia.

Below is a collection of past articles and podcasts exploring such tactics. My hope is that this content can serve as helpful resources to dive deeper into this topic as well as support your ongoing longevity journey.

#164 – Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia

“At the end of the day, it really has to do with how people see themselves, how people interact with the world, what kind of relationships they have, how able they are to let go of things that they’ve lost and how able they are to focus on the positive.”  —Amanda Smith

#152 – Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)

If you have good programming, dosing, loading, timing, recovery, and on top of that, you have amazing body awareness and cortical function, you’re going to see longevity and you’re going to see nice quality of movement.” –Michael Rintala

#147 – Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s

“What’s important is in science, you always have to be skeptical and you always need to find whether any particular study can be replicated or not before you make strong recommendations and adopt any drastic change and how you are consuming certain things, whether it’s a medication or a diet or a supplement.” — Hussein Yassine, M.D.

#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives

“Believe it or not, there are 46 million Americans with Alzheimer’s disease in their brain right now, but no symptoms.” — Richard Isaacson

Q&A on Alzheimer’s disease drug therapy with Dr. Richard Isaacson

Check out more content with neurologist, Richard Isaacson, M.D.: (Oct 1, 2018) #18 – Richard Isaacson, M.D.: Alzheimer’s prevention (Nov…

Robin Williams

This Tuesday marks the tragic anniversary of the death of Robin Williams.

#120 – AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

“The function of the mitochondria and mitochondrial health are the ultimate mitigator of neurodegenerative diseases…just by reducing the potential for reactive oxygen species related damage.” — Dom D’Agostino

#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

Alzheimer’s disease and glucose metabolism

“In Alzheimer’s Research, Glucose Metabolism Moves to Center Stage.”

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