Category

Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

Qualys #101 – What the hell does insulin resistance actually mean?

This episode of The Qualys is from podcast #33 — Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin — which was originally released on December 17, 2018.

Peter Attia on How Insulin Resistance Manifests in the Muscle

“If you’re in the business of wanting to live the healthiest life you can live, which means longer and better, you’ve got to be insulin sensitive, full stop.” — Peter Attia

#194 – How fructose drives metabolic disease | Rick Johnson, M.D.

Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson

Low LDL cholesterol and neural development

Why LDL-lowering treatments don’t pit head against heart

Not another COVID newsletter

In last week’s newsletter on vaccine mandates, I implored you all to think. Many of you rose to the occasion with insightful feedback.

#192 – COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more

“I think people are starving out there for honesty on this topic that’s not tribal” – Marty Makary

Why I’m for COVID vaccines, but against vaccine mandates.

In the heated debate over vaccine mandates, science and logic have often been lost amid politics and fear.

Are we oversimplifying Alzheimer’s disease?

A proposal for 4 subtypes of Alzheimer’s disease.

#189 – COVID Part 1: Current state of affairs, Omicron, and a search for the end game

Where’s the humility? People are hungry for honesty right now.” —Marty Makary

#187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory

“I think [Otto Warburg’s] influence is much wider than many people realize… he ended up having a massive influence on American life. Just nobody knows about it.” —Sam Apple

Facebook icon Twitter icon Instagram icon Pinterest icon Google+ icon YouTube icon LinkedIn icon Contact icon