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Metabolic disease

One way to think about metabolic disease is as a disorder in fuel processing. Whether we’re talking about hyperinsulinemia or type 2 diabetes, the fundamental problem is that the body is not doing a good job storing and accessing fuel.

I think of the three most deadly chronic diseases — heart disease, cancer, and dementia — as pillars all resting on the foundation of metabolic disease. While complications from metabolic disease often do not directly lead to death, the indirect cost is staggering. Each of the other major pillars of chronic disease is exacerbated and amplified by metabolic dysregulation.

Metabolic disease typically exists on a continuum — progressing from hyperinsulinemia, to insulin resistance, to non-alcoholic fatty liver disease, all the way to type 2 diabetes — and tends to cluster with five signs which make up the diagnostic criteria for Metabolic Syndrome, including: high blood pressure, elevated triglycerides, elevated blood glucose, truncal obesity, and low HDL-cholesterol.

The following is a collection of content that dives deeper into the topic of metabolic health, discussing specific strategies for prevention and treatment.

Can a father’s metformin cause birth defects in his sons?

Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.

#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

“I really think that in 10 years we’re going to basically be using designer-based immunotherapies to eradicate most solid organ metastatic cancers.” —Peter Attia

How deadly is type 2 diabetes?

Diabetes was only the 8th-leading cause of death in 2020. Can it really be possible that diabetes is so “harmless” relative to the other major chronic diseases, or are the CDC reports only the tip of the iceberg?

Visceral Fat vs. Subcutaneous Fat — What’s the Difference?

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Rick Johnson, M.D. on the impact of high blood pressure on chronic disease

This video clip is taken from  Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson…

Rick Johnson, M.D. on the relationship between salt & blood pressure

This video clip is taken from  Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson…

Peter Attia on mitigating and reversing insulin resistance with nutrition

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Peter Attia on the connection between stress and insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Peter Attia on the role of exercise in mitigating and reversing insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #20, originally released on February 15, 2021. If you’re a member, you…

Qualys #168 – Sleep and insulin resistance with Matthew Walker, Ph.D.

This episode of The Qualys is from podcast #33 — Matthew Walker, Ph.D., on sleep Part III — which was originally released on April 15, 2019.

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