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The mouse trap: lost in translation?
“The great majority of how we understand disease, and attempt to cure it,” writes Engber, “derives from a couple of rodents.” About 4/5ths of all animal studies reported in biomedical research papers from 1950-2010 were done in rodents (59% in mice, 18% in rats).
Ketones, fasting, and muscle loss
I read an interesting article authored by my friend Dom D’Agostino and his colleagues on the anti-catabolic effects of ketone bodies in skeletal muscle.
Wanna know what keeps me up at night?
Unfortunately, the answer is: We have no clue what the best protocol is for intermittent fasting (fasting that is done periodically, and not to be confused with time restricted feeding).
#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin
“I’ve always felt that it was really somehow an enormous opportunity and a gift to be able to pursue this down to the level that I’ve been able to do in the past 30 years.” —Rudy Leibel
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
“I pay more attention today to stress than anything else.” —Nav Chandel
#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system
“Neurons like to be tickled, not bludgeoned.” —Rob Lustig
#11 – AMA #2: the Nothingburger — results from Peter’s week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting
“Not everything that can be counted counts, and not everything that counts can be counted.” —William Bruce Cameron
Salmon recipe (and mTOR)
By popular demand, I’m sharing my Dad’s salmon recipe
The Nothingburger and my favorite interview
Interesting three weeks with the “Nothingburger” experiment: one week of fasting sandwiched between two weeks of nutritional ketosis.
Fasting and conserving energy
I think most casual fans of cycling know that riding in a peloton can provide an energy savings, but this just floored me