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#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
#65 – Rick Doblin, Ph.D.: MDMA — the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species
“I think that there’s a fundamental human right that people have to explore their consciousness. . .I believe we should have a system of licensed legalization [for psychedelics].” — Rick Doblin
#64 – Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions
“A good surgeon knows how to take care of any complication they create.” — Zol Kryger
#63 – AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more
“The single greatest risk to my longevity is my lower back.” —Peter Attia
#62 – Keith Flaherty, M.D.: Deep dive into cancer— History of oncology, novel approaches to treatment, and the exciting and hopeful future
“We can’t keep hitting the same pillar and expect that we’re going to cure cancer. . .we need the activators of the immune system, we need the inhibitors of the activated oncogenes, we need the drugs that target epigenetic regulators, and we need the metabolic switch regulators.” — Keith Flaherty
#61 – Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology
“This is where an MRI becomes a beautiful machine in the fact that it actually allows you to take the ‘yes or no’ binary answer of functional nuclear medicine and combine it with the anatomic localization and understanding of tissue types of radiology. . .I merged those two together on the one machine.” — Raj Attariwala
The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead
“I was surprised by how much fun I had doing this, I was surprised by the feedback we got from folks that kind of dug it, and so even if the world doesn’t need another podcast, we’re just gonna keep doing this.” — Peter Attia, reflecting on the first year of doing the podcast
#60 – Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply ‘backcasting’ to boost your odds for future success
“We don’t want [people] to be afraid of the bad outcomes. . .because we would like people to be innovative and push against the status quo because that’s how we move forward as a society, as a business, as an individual.” — Annie Duke
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep
“[Sleep] is like that master volume button on a mixing deck that you see in the studio. You can manipulate each one of those dials, or you can go to the far left and just move that one dial…and all of the other levers seem to move with it.” — Matthew Walker