#51 – Robert Sapolsky, Ph.D.: The pervasive effect of stress – is it killing you?
“The [stress response] system has been serving vertebrates, doing a lot of help for them for an awful long time, and it’s only been a very recent modification to instead secrete [cortisol] in response to thinking about taxes.” —Robert Sapolsky
#50 – AMA #5: calcium scores, Centenarian Decathlon™, exercise, muscle glycogen, keto, and more
“We’re really talking a completely new model, which is actually forcing your way to become a centenarian rather than just sort of gliding your way into it and therefore, I think it’s going to require much more deliberate attention around what your mind and body are doing at that point and time.” — Peter Attia
#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleep
“Lack of sleep is like a broken water pipe in your home. It will leak down into every nook and cranny of your physiology.” —Matthew Walker
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)
“If there is one central, common pathway through which we can understand almost all aspects of the deleterious impact of insufficient sleep, it is…an excessive leaning on the fight or flight branch of the nervous system.” — Matthew Walker
#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer’s risk, mental health, memory consolidation, and more
“I think that sleep may be one of the most significant lifestyle factors that determines your risk ratio for Alzheimer’s disease.” — Matthew Walker
#46 – Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease – NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more
“People are gonna make a decision to. . . either wait 10 or 20 years until we know something better, or you take the position that you’re going to tinker. And if you’re going to tinker, you’re a lot more successful if you have a working model of what’s going on than if you don’t.” —Chris Masterjohn
#45 – AMA #4: sleep, jet lag protocol, autophagy, metformin, and more
“Every day in the human body, some 10 billion cells die and are replaced by new cells.” —Nick Lane
#44 – Jeremy Schaap, ESPN journalist: upsets, doping, triumphs, and the importance of sports
“Fairness is the underpinning of everything. It’s not just about being fair to the subject. It’s about being fair to the audience. It’s about being fair to the story, and fair to the truth.” —Jeremy Schaap
#43 – Alan Bauman, M.D.: The science of male and female hair restoration – how to protect, enhance, and restore the appearance and health of the hair and scalp
“When [a patient] looks in the mirror and sees that hairline growing back in and says, ‘I would never have thought I would see my hairline again. I never thought I’d cover that bald spot.’ I mean, that’s the exciting thing that keeps me going every day.” —Alan Bauman
#42 – Avrum Bluming, M.D. and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer
“We welcome the criticism and the discussion, that way we will all learn. We don’t claim to have the final answer, but we think that this book [Estrogen Matters] represents an important step forward in empowering women and helping them live longer and live better.” —Avrum Bluming