Category

Medications, Supplements & Other Treatments

In our practice, we organize longevity tactics into five domains — one of which I call ‘exogenous molecules,’ a fancy way of talking about medications, supplements, hormones, or any other formulated molecule you put into your body. Although powerful, this tactic can be challenging to discuss as it is highly individual. So instead of telling you to “take X” or “never take Y,” I find it more beneficial to approach this tactic with a 3-part framework:

(1) What is the objective? The more clearly you can define your objective, the more clearly you can assess if this is the right tool for accomplishing that objective

(2) Is there a biomarker? How do you plan to customize, track, and adjust your treatment over time? If there is no biomarker to monitor as a measure of effectiveness, it doesn’t mean you shouldn’t take the supplement or medication; it just means you may need to be more intentional around monitoring results in other ways.

(3) Does the risk outweigh the reward? Everyone has a different tolerance for risk. Some questions to consider when weighing risk vs. reward: What is the mechanism of action? How many patient years of use exist? What are the short-term and long-term risks of taking the medication? What are the risks of not taking the medication?

Below is a collection of past content discussing some common supplements, medications, and other treatments.

#180 – AMA #28: All things testosterone and testosterone replacement therapy

“There were countless other studies to look at, but they all basically point in the same direction, which is testosterone replacement therapy improves lean mass, reduces fat mass, improves strength.” —Peter Attia

#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions

Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia

#170 – AMA #25: Navigating the complexities and nuances of cancer screening

We screen often, we screen early, and we screen aggressively.” —Peter Attia

A new frontier for early cancer detection?

Discussing the GRAIL blood test

#166 – Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease

“You can maintain optimal oral health just by brushing teeth, by flossing really well, and having good nutrition.” —Pat Corby

A hope for treating Alzheimer’s disease?

The FDA approves the first new medication for AD, aducanumab, in two decades

MDMA for PTSD?

MDMA-assisted therapy gets one step closer to its projected 2023 FDA approval

Psilocybin for depression?

The psychedelic drug goes head-to-head with Lexapro in a recent trial

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