Category

Medications, Supplements & Other Treatments

In our practice, we organize longevity tactics into five domains — one of which I call ‘exogenous molecules,’ a fancy way of talking about medications, supplements, hormones, or any other formulated molecule you put into your body. Although powerful, this tactic can be challenging to discuss as it is highly individual. So instead of telling you to “take X” or “never take Y,” I find it more beneficial to approach this tactic with a 3-part framework:

(1) What is the objective? The more clearly you can define your objective, the more clearly you can assess if this is the right tool for accomplishing that objective

(2) Is there a biomarker? How do you plan to customize, track, and adjust your treatment over time? If there is no biomarker to monitor as a measure of effectiveness, it doesn’t mean you shouldn’t take the supplement or medication; it just means you may need to be more intentional around monitoring results in other ways.

(3) Does the risk outweigh the reward? Everyone has a different tolerance for risk. Some questions to consider when weighing risk vs. reward: What is the mechanism of action? How many patient years of use exist? What are the short-term and long-term risks of taking the medication? What are the risks of not taking the medication?

Below is a collection of past content discussing some common supplements, medications, and other treatments.

The potential of probiotics in promoting female health

Maintaining a healthy vaginal microbiome is key for female urogenital health, and existing evidence suggests that probiotics may be beneficial

#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers

This paper basically addresses how our beliefs about the drugs we take impacts how they affect us at a real level, not just at a subjective level, but at a biological level.” —Andrew Huberman

#264 ‒ Hip, knee, ankle, and foot: diagnosis, treatment, and surgery of the lower extremities | Adam Cohen, M.D.

Just like we talked about in the shoulder, and the knee, and the hip, any mechanical trauma to the joint puts you at increased risk for arthritis of that joint.” —Adam Cohen

#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.

If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins

First anti-inflammatory medication approved for treatment of ASCVD

Low-dose colchicine, an anti-inflammatory drug, was recently approved by the FDA to reduce risk of cardiovascular events

#262 – AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health

[Heart rate recovery] is one of the metrics that we should care about just as we care about VO2 max and just as we care about resting heart rate.” —Peter Attia

#260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H.

Clinicians don’t ask about it. Patients are embarrassed to ask about it. And that’s the suffering in silence.” —Mohit Khera

Taurine improves the health and longevity of mice and monkeys – but what about humans?

A new study set off a media storm over taurine’s potential in delaying aging and extending lifespan. Great news – if you’re a mouse.

#259 – Women’s sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D.

I can’t tell you how many women soldier on either avoiding sex or in pain because they don’t either know or feel validated to seek treatment.” —Sharon Parish

Separating substance from nonsense in a study on NMN supplements

A recent randomized trial investigated the effect of NMN supplementation on NAD levels, biological aging, and exercise performance. What can we believe from their results?

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