April 11, 2012

Biochemistry

Gravity and insulin: the dynamic duo

by Peter Attia

Read Time 10 minutes

Last week I wrote about how carbohydrates are effectively a performance-enhancing substance, at least for certain performances in certain people.  I received many great questions, including some challenging this suggestion, which really pleases me because it demonstrates folks are thinking about tradeoffs and questioning everything.

Is carbohydrate reduction or outright restriction “right” for everyone?  I doubt it.  Besides oxygen and water the list of “universal truths” for human health is pretty short.  Parenthetically, one can still overdose on both oxygen and water – in other words, even these two completely essential compounds can be toxic outside of their ideal ranges.

If you’ve been following this blog and/or this general discussion, you’ve probably asked yourself the question I’m about to pose.  If you haven’t asked it yourself, you’ve likely been asked by someone as you’ve had the discussion with friends or family.  Here’s the question:

If insulin is so important in regulating fat metabolism, why do some people eat whatever they want and not get fat? Conversely, why do some people following the strictest carbohydrate-reduced diet remain fat?

This is a paramount question, and I’m sorry it’s taken me four months to finally get to it.  Before we do get to it let me digress (seemingly) to discuss gravity.  If you know everything about gravitational forces, feel free to skip this section.

 

What is gravity?

 

For the purpose of simplicity I will limit this discussion to Newton’s law of universal gravitation, as it applies to virtually any “gravity scenario” we encounter in our lives, and it’s the law everyone thinks of when they hear the word “gravity.”  Newton’s law of universal gravitation states that every mass in the universe attracts every other mass with a force that is directly proportional to the product of their masses and inversely proportional to the square of the distance between them.

For those, like me, who love equations, here it is:

 

Gravitation

In this equation, m1 and m2 are the masses of the two spheres, and r is the distance between them.  G is a really, really, really tiny number called the gravitational constant which, as its name suggests, is a constant.

In other words, objects in the universe have attractive forces between them. These attractive forces depend on two things: the masses of the objects (the more the mass, the more the force, since mass is in the top of the equation) and the distance between them (the more the distance between them, the less the force, since distance – squared – is in the bottom of the equation).  No other amount of detail is really necessary to understand the point I’m going to make.

For most objects on earth (excluding the earth), this force of gravitation is actually not particularly dominant.  When I’m standing next to someone, neither of us can feel this force for two reasons: 1) our masses are not high enough, and 2) the distance between us is too great to overcome the really, really, really tiny gravitational constant.  For example, two 80 kg people standing even 1 cm apart only exert 0.004 Newtons on each other, which is completely unnoticeable.  [A Newton is the unit we use to measure force.]

It turns out for most objects on earth that we interact with, gravitational force is irrelevant (actually, it’s what we’d call a “higher order term” if you remember my discussion of ordered terms, or relative importance from this post).  But there is one enormous exception: the earth!  Because the earth weighs so much (about 6 trillion trillion kilograms; no, that’s not a typo – 6 followed by 24 zeros) for pretty much any object on earth ranging from a feather to a 747 to a skyscraper, the force the earth exerts on us (and us back on her) is equal to our own mass multiplied by 9.8 meters per second per second (this number is the acceleration we experience due to gravity).  You can verify this for yourself using the equation above (plug in your mass, the mass of the earth, and the distance from you to the center of the earth).

This is a long way of getting to one of the most often experienced applications of Newton’s Second Law: the net force that acts on a body is equal to the mass of that body multiplied by the change in the mass’s velocity (referred to as acceleration).   When you drop an object, the earth is pulling it towards itself with a force equal to the mass of object multiplied by 9.8 meters per second per second (this unit of m/s/s is the unit for acceleration – the rate of change of velocity).

Here’s a more visceral example: When you are in an airplane taking off on the runway you feel an enormous force on your back, though you’re traveling much slower than when in full flight, when you feel nothing.  Why? In full flight acceleration is zero – velocity, albeit high, is constant – so you feel no force.  On the runway, the plane is accelerating (i.e., changing velocity), so you feeeeel it.

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Leaving a wide plume of flame as it climbed into the thin atmosphere of high altitude, the 363 foot tall, 6,400,000 pound Saturn V rocket hurled the spacecraft into Earth parking orbit and then placed it on the trajectory to the moon. Nasa.gov

Why did I just explain all of this?

We live in a world that is governed by physical laws, of which Newton’s laws are but an important subset.  Do you need to know them?  Nope.  Does understanding them change them?  Nope.  Can you “will” your way out of them? Nope.  Is it better to know them or be completely oblivious of them?  I guess it depends on your personality.  I prefer to know as much as possible about the physical world I live in.  It keeps me safe.

Some of you know everything about gravity that I just explained, and then some.  Some of you just heard it for the first time.  Regardless, the laws of gravitation are universally true and apply to every single one of us, whether we like or are aware of it or not.  Let’s consider a few examples.

Look at this fellow:

 

 

Photo by Karina Carvalho on Unsplash

Or this fellow:

 

Photo by Sergio Rao on Unsplash

Are they “defying gravity?”

Are they experiencing a “different” form of gravity than, say, this fellow?

 

By http://www.flickr.com/photos/theeerin/4112368718/in/photostream/ [CC BY-SA 2.0], via Wikimedia Commons
Or this fellow?

 

Photo by Robert and Pat Rodgers is licensed under CC by 2.0

Not at all.  In fact, each of these four men is actually subject to the exact same universal truth of gravity.  So, why do the first two appear to challenge the law of gravity while the second two appear to exaggerate the law of gravity?

Lots of reasons, probably, but the two most obvious are differences in genetics and differences in conditioning.  What about the guy belly flopping into the pool? Not quite the same genes and nowhere near the same level of conditioning as someone who seemingly defies gravity.  As a result, the impact of gravity is more obvious on them.

Here’s another example:  Consider a ledge 10 feet off the ground.  Let’s line these three gentlemen up and ask each of them to jump off the exact same ledge.

 

Different types

The same law of gravity applies to each of them. No exceptions. Will they all experience the law of gravity in the same way?  Of course, not.  First guy – no problem.  Second guy – probably breaks his leg.  Third guy – probably dies.

Let’s add one more layer of complexity to this.  When I was 16 years old, I could jump off a 10 foot ledge with zero difficulty.  Today, at 39, it would take a bit of practice and a lot of concentration to avoid spraining my ankle and tearing a ligament in my knee.  When I’m 65, I’ll be lucky not to break my leg.  When I’m 85, I’ll be lucky not to break my neck.  Why?  Same gravity, right?  Same genes, right? Yet over time, I will experience gravity differently.  Changes in my body over time lead to a differential experience of the same physical laws.

 

How does insulin fit into this discussion?

Insulin is the most important hormone in our body when it comes to fat mobilization (breakdown) and fat storage.  This is a fact.  There is not one person who studies the endocrine system who will not acknowledge the following quote from Lehninger’s Principles of Biochemistry (the “bible” of biochemistry).

“High blood glucose elicits the release of insulin, which speeds the uptake of glucose by tissues and favors the storage of fuels as glycogen and triglycerides, while inhibiting fatty acid mobilization in adipose tissue.”

In other words, eating glucose (carbohydrates) increases insulin levels in our body.  Insulin drives glucose into liver and muscle cells as glycogen (in small, finite amounts) and into fat cells as triglycerides (in unlimited amounts). Insulin also inhibits the breakdown and utilization of fat, as shown here.

Insulin does not act alone, and the story of fat storage and breakdown is complex if you want to understand every single detail, but the “first order term” is insulin.  I will spend time in the future writing about insulin’s “dance partner,” leptin.  But insulin is probably the General when it comes to determining how the body partitions fat.

So, insulin is sort of like gravity.  It’s in your body whether you know about it or not.  It’s acting on your cells whether you like it or not.  It’s playing a major role in determining your ability to mobilize versus store fat if you believe me or not.

Does this mean insulin has the same effect on everyone?  Does this mean insulin has the same effect on any given person over time? Of course not. Contrast me and my wife.  I look at carbohydrates and start to store fat. If you want a reminder of what I looked like on an “athlete’s diet” of complex carbs and little saturated fat, coupled with 3 to 4 hours of exercise a day, look here, here, and here.  On the other hand, my wife can eat a bag of Oreo cookies for dinner every night, coupled with all the pasta, bread, and rice the world has to offer and not put on one pound (she has weighed about 110 pounds her entire adult life).  How is this possible?  Does this mean insulin doesn’t control fat metabolism?  No, it means we have an entirely different genetic make-up.  Her grandmother is 86 years old, eats bread all day long, is healthy as a horse, and weighs 100 pounds. Conversely, I come from a family where every single man has died of heart disease and looked like the Pillsbury Dough Boy prior to doing so.  I’m genetically programmed to lean towards metabolic syndrome, but I’ve been able to reverse it through strict attention to my eating habits.

This isn’t unique to me and my wife. There is an entire spectrum – a distribution across the population – of people with varying degrees of susceptibilities to the effects of carbohydrate on insulin levels and the commensurate effects of insulin levels on fat storage and breakdown.

And like gravity, the effect of insulin on our metabolism of fat changes over time at the individual level, usually for the worse.

Consider, again, my example: When I was 16 years old I weighed 160 pounds, had between 4 and 5% body fat, a 28-inch waist and a 44-inch chest.  Breakfast consisted of a box (not a bowl) of cereal.  Lunch consisted of 7 turkey and tuna sandwiches (yes, 14 pieces of bread), a gallon of apple juice, and a plate of fries and gravy.  Dinner was a pound of pasta and half a chicken.  Despite eating over 1,000 gm of carbohydrate per day, I was quite resistant to them (i.e., I was very insulin sensitive) and remained exceptionally lean.

Fast forward to three years ago, at the age of 36, I weighed 200 pounds, had 25% body fat, a 36-inch waist and a 44-inch chest.  What changed over 20 years?  I was actually eating considerably less – in both absolute amounts and total carbohydrates – and yes, I was exercising a bit less (3 to 4 hours per day at 36 versus 6 hours per day when I was 16). But, is that the only thing that changed?  What changed in me, and what changes in most people over the same period of their lives, is that I became progressively more insulin resistant.  Most people casually observe that their “metabolism slows down” as they age, but what really happens?

I wish I could definitively tell you why this happens. I can’t. What I can tell you is how it happens. There are many factors, and they certainly vary by person and by individual significance.  The list below is a bit simplified and by no means complete.

  1. Over time, endogenous production of sex hormones (e.g., testosterone, estrogen) becomes altered, and this seems to play a role in fat metabolism.  In addition to sex hormones, other non-sex steroid hormones (e.g., cortisol), which have a strong effect on fat metabolism, may be altered for a variety of reasons including sleep reduction and stress.
  2. Perhaps (at least partially) related to this, the cellular distribution and density of lipoprotein lipase (LPL) also changes.  [Recall, LPL is a very important enzyme on the surface of muscle cells and fat cells.  On muscle cells, it fosters fat oxidation (good). On fat cells, it fosters fat accumulation (bad).]  As we age, we tend to have less LPL on muscle cells and more LPL on fat cells, both of which contribution to fat accumulation rather than fat oxidation.
  3. The membranes of our cells tend to change in fatty acid composition, which may result in more difficulty getting the GLUT-4 transporter into cell membranes to foster glucose flux into cells.  The more difficult it is to get glucose into cells, the more insulin the pancreas must secrete to exert its eventual effect, the more exposure all cells have to circulating insulin levels.  Higher levels of insulin also exacerbate the phenomenon of more LPL on fat cells and reduced fat oxidation.

These changes are all linked, and probably play a different role of importance in different people at different times in our lives.

 

So what do gravity and insulin have in common?

The forces of gravity and effects of insulin are natural phenomena.  Sure, the comparison is not perfect, but it serves a very important purpose in making the following case:

  1. These forces act on us whether we know it or not and whether we like it or not.
  2. The net impact of these forces on you is highly dependent on your genes, your age, and the choices you make (e.g., practicing gymnastics versus siting on the couch, changing your eating habits versus eating the same old standard foods).
  3. Just because some people seem to “defy” these forces does not negate their existence.  Michael Jordan dunking from the top of the free throw line doesn’t mean I can and doesn’t mean gravity is irrelevant.
  4. What matters most is how these forces act on you. Be less concerned with the folks who lie to either side of you on the population distribution curve (i.e., those more or less impacted by gravity or insulin).  Figure out what works for you and be ready to modify the plan over time, because it will likely get less and less easy to maintain and improve your performance over time.  We may not be able to outrun Father Time, but we can keep him at bay.

 

Astronaut Robert L. Stewart, Mission Specialist (MS), uses his hands to control his movement in space while using the nitrogen propelled Manned Maneuvering Unit (MMU). He is participating in a EVA, a few meters away from the cabin of the Shuttle Challenger. MS Stewart is centered in a background of clouds and Earth in this view of his EVA. He is floating without tethers attaching him to the Shuttle. Nasa.gov

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