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#19 – Dave Feldman: stress testing the lipid energy model
“I am on a journey of science, not of advocacy: I’m going to be quite a skeptic.” —Dave Feldman
#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
“Use the correct terminology with everything.” –Tom Dayspring
#41 – Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights
“You have this unique population of [type 1 diabetics] where you can see the insulin that goes into them, and you can see it’s direct impact on weight gain. . . and they’re at risk for cardiovascular illness. And to me that just says that there’s something about the Standard American Diet that’s making us sick. And ultimately we will all be at risk for cardiovascular disease.” —Jake Kushner
The mouse trap: lost in translation?
“The great majority of how we understand disease, and attempt to cure it,” writes Engber, “derives from a couple of rodents.” About 4/5ths of all animal studies reported in biomedical research papers from 1950-2010 were done in rodents (59% in mice, 18% in rats).
Is there an optimal window of time-restricted feeding?
Breakfast like a king, lunch like a prince, and dine like a pauper?
Can you preserve lean body mass during “semi-starvation?”
All of this is very interesting, but what I find much more interesting in this study is that the placebo group did not lose any substantive LBM, while losing about the same amount of fat (10 lb) as the testosterone group, despite the severe CR/energy-deficit.
My nutritional framework
Nutrition is such a loaded topic—almost a religious or political one—so I’m always looking for ways to explain it that are as free from that baggage as possible.
#92 – AMA #12: Strategies for longevity (which don’t require a doctor)
“If you are interested in longevity, if you are interested in playing with your great grandkids, you want to prioritize muscle mass. Never in the history of civilization has a 90 year old said, ‘I wish I had less muscle.’” —Peter Attia
#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico
“Skeletal muscles are the greatest reservoir that you have for glucose disposal.” —Peter Attia
#194 – How fructose drives metabolic disease | Rick Johnson, M.D.
“Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson