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diabetes

Medications, Supplements & Other Treatments

Can a father’s metformin cause birth defects in his sons?

Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.

Cardiovascular Disease

#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

“One of the things that is so dangerous about this disorder is that the plaque that you get in FH is a soft plaque.” —John Kastelein

Medications, Supplements & Other Treatments

A recent metformin study casts doubts on longevity indications

A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.

Metabolic disease

#271 – AMA #51: Understanding and improving your metabolic health

Zone 2 output is arguably the most important functional test we have of metabolic health.” —Peter Attia

Preventing Chronic Disease

Is Type 2 Diabetes Reversible at Scale?

If you’re reading this, you probably know that I’m obsessed with longevity.

Science of Aging

#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?

“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha

Nutritional Biochemistry

#87 – Rick Johnson, M.D.: Metabolic Effects of Fructose

“Fructose turns out to be used by animals as a mechanism to store fat.” — Rick Johnson

Understanding science

Success versus Failure: A stark juxtaposition

What does winning, and losing, look like when confronting public health issues?

Medications, Supplements & Other Treatments

#180 – AMA #28: All things testosterone and testosterone replacement therapy

“There were countless other studies to look at, but they all basically point in the same direction, which is testosterone replacement therapy improves lean mass, reduces fat mass, improves strength.” —Peter Attia

Nutritional Biochemistry

#194 – How fructose drives metabolic disease | Rick Johnson, M.D.

Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson

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