#187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory
“I think [Otto Warburg’s] influence is much wider than many people realize… he ended up having a massive influence on American life. Just nobody knows about it.” —Sam Apple
#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions
“Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia
#149 – AMA #20: Simplifying the complexities of insulin resistance: how it’s measured, how it manifests in the muscle and liver, and what we can do about it
“If you’re in the business of wanting to live the healthiest life you can live, which means longer and better, you’ve got to be insulin sensitive, full stop.” — Peter Attia
#141 – AMA #18: Deep dive: sugar and sugar substitutes
“Is glucose a sugar? Yes. Is fructose a sugar? Yes. Are they the same? Not even close.” —Peter Attia
#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico
“Skeletal muscles are the greatest reservoir that you have for glucose disposal.” —Peter Attia
#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley
#88 – Paul Grewal, M.D.: Treating metabolic disease and strategies for long-term health
“You could say our food supply has changed more in the last 100 years than it has in the last 10,000.” — Paul Grewal
#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
“The way we raise our kids early on might actually set a pattern for how much of an accelerated life, or how much of a stressed out nervous system they might have later on. . . a lot of the behavioral patterns that we’re instilling in our kids are kind of setting the foundation for insulin resistance and inflammation early on.” —Ronesh Sinha
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung