#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#111 – AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity
“Metabolic health really matters. It is the common thread that links all of these chronic diseases.” — Peter Attia
Qualy #82 – What is the most common first presentation of heart disease?
Today’s episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease.
Measuring cardiovascular disease risk and the importance of apoB
Millions of Americans schedule an annual physical health examination. During their visit, many can expect to get their blood drawn for a standard lipid panel, which ultimately provides the patient with a readout of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs). What virtually nobody among them will get is…
Coronary artery calcium scan
After last week’s deep dive into the relationship between LDL cholesterol, systolic blood pressure, and cardiovascular disease, I thought it would not hurt to go a bit deeper in the weeds. You’ll recall that atherosclerosis takes the greatest proportion of lives when people are in their later years, but it’s a disease that takes a…
LDL-C & systolic blood pressure and lifetime risk of cardiovascular disease
Mendelian randomization and lifetime cardiovascular disease risk.
Qualy #46 – Rapamycin’s effects on cancer, cardiovascular disease, and neurodegeneration
Today’s episode of The Qualys is from podcast #09 – David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?.
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
Skipping breakfast
Nota bene: I was pretty pissed off when I wrote this, but don’t let my annoyance detract from the message. Bad science is an abomination. Incompetent news reporting on bad science is worse.
#52 – Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone – two topics that are surprising interrelated
“Primary prevention is still very much art and not science and probably will be for our lifetime so we’ll have to get used to that.” —Ethan Weiss