Tag

Diseases – type 2 diabetes

Ketosis

#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino

Fasting

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

Diseases

#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley

Diseases

Alzheimer’s disease and glucose metabolism

“In Alzheimer’s Research, Glucose Metabolism Moves to Center Stage.”

Aging

#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?

“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha

Fasting

#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness

“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective.  . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung

Treatments

Metformin and exercise

If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.

Diseases

#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM

“One of the most humbling things about this job is when I meet the children or the adult patients who has had this device change their life . . . it’s really why we come to work every day, what keeps us going.” —Kevin Sayer

Treatments

#42 – Avrum Bluming, M.D. and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer

“We welcome the criticism and the discussion, that way we will all learn. We don’t claim to have the final answer, but we think that this book [Estrogen Matters] represents an important step forward in empowering women and helping them live longer and live better.” —Avrum Bluming

Fasting

Calorie restriction?

In case you missed it, there’s a new series on calorie restriction (CR) up on the site.

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