Tag

Drugs – metformin

Treatments

#184 – AMA #29: GLP-1 Agonists – The Future of Treating Obesity?

“Getting deeper into how this drug works has certainly made me appreciate its power.” —Peter Attia

Aging

#175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

“I don’t think I will ever understand aging fully. And I don’t think the field will. … But I also believe that we don’t have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein

Aging

#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules

“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad

COVID-19

Metformin and COVID-19 mortality risk; a timeline of Kobe’s last day

A few things worth checking out: 03-28-2021

Treatments

#148 – Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program

“I don’t really care what causes aging. What I care about is: What is the process that can postpone all the different aspects of aging?” — Rich Miller

Nutritional biochemistry

#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman

Aging

#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19

“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick

Ketosis

#120 – AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

“The function of the mitochondria and mitochondrial health are the ultimate mitigator of neurodegenerative diseases…just by reducing the potential for reactive oxygen species related damage.” — Dom D’Agostino

Aging

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein

Fasting

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

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