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#89 – AMA #11: All things fasting
“Truthfully, in humans, we don’t necessarily know exactly what the dose curve looks like for duration of fasting to physiologic output of desired consequence.” —Peter Attia
A new year
A couple of unrelated events over the past few months have led me to view 2020 as a year to implement some new routines around my mental and emotional health.
#85 – Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health
“What I have been seeing for 25 years, working with elite athletes, is that [zone 2] is the exercise intensity where I see the biggest improvement in fat burning and the biggest improvement in lactic clearance capacity. Therefore, that means that the mitochondria is where you see the biggest improvement.” —Iñigo San Millán, Ph.D.
#84 – AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting)
“Milk is for babies. When you grow up you have to drink beer.” —Arnold Schwarzenegger
#80 – Celebrity AMA with Apolo Ohno and Sasha Cohen: Fasting, rapamycin, performance vs. longevity, and more
“I am obsessed with knowing stuff. There’s just no denying it.” — Peter Attia
Metformin and exercise – déjà vu all over again?
Metformin blunts muscle hypertrophy in response to progressive resistance training
#73 – AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more
“The sky is blue, and the trees are green; therefore, I should eat cyanide.” — Peter Attia on the type of brilliant logic people use to suggest you burn more calories while sleeping vs. exercising
#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
“The way we raise our kids early on might actually set a pattern for how much of an accelerated life, or how much of a stressed out nervous system they might have later on. . . a lot of the behavioral patterns that we’re instilling in our kids are kind of setting the foundation for insulin resistance and inflammation early on.” —Ronesh Sinha
Can you maintain muscle during fasting?
But in the short-term (at least up to a week for most people), I believe you can maintain muscle mass while fasting, particularly if you’re resistance training.
Can you preserve lean body mass during “semi-starvation?”
All of this is very interesting, but what I find much more interesting in this study is that the placebo group did not lose any substantive LBM, while losing about the same amount of fat (10 lb) as the testosterone group, despite the severe CR/energy-deficit.