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#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.
“Most 40 year olds, 50 year olds, they have pain anyway. So I’d rather be strong and have pain than be weak and have pain.” —Layne Norton
#227 – AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more
“We don’t want to be consuming protein for energy purposes at all. We want to be consuming protein for muscle protein synthesis.” —Peter Attia
#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino
#89 – AMA #11: All things fasting
“Truthfully, in humans, we don’t necessarily know exactly what the dose curve looks like for duration of fasting to physiologic output of desired consequence.” —Peter Attia
Intermittent fasting
Metabolic switching and different forms of fasting.
My nutritional framework
Nutrition is such a loaded topic—almost a religious or political one—so I’m always looking for ways to explain it that are as free from that baggage as possible.
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
#53 – AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more
“Time is the only truly finite resource that we have. It is also the only unifying, equalizing resource. Meaning, no matter how much wealth or smarts or whatever you have, we are all stuck with the same disappearing thing.” — Peter Attia
The mouse trap: lost in translation?
“The great majority of how we understand disease, and attempt to cure it,” writes Engber, “derives from a couple of rodents.” About 4/5ths of all animal studies reported in biomedical research papers from 1950-2010 were done in rodents (59% in mice, 18% in rats).
Wanna know what keeps me up at night?
Unfortunately, the answer is: We have no clue what the best protocol is for intermittent fasting (fasting that is done periodically, and not to be confused with time restricted feeding).