#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules
“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad
#145 – AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor
In this “Ask Me Anything” (AMA) episode, Peter and Bob take a deep dive into zone 2 training. They begin…
#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman
#127 – AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
“Could we think that sleep could now provide a contribution to this Horvath clock of determining your biological age? . . .I think it probably does.” —Matthew Walker, Ph.D.
A few things worth sharing: 08-30-2020
Shitty first drafts and accelerating fasts.
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein
#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
“I think once people enter that seventh and eighth decade, if they haven’t done a lot of consistent preparatory work in the decades prior, it’s alarming how quickly things go south.” —Peter Attia
#89 – AMA #11: All things fasting
“Truthfully, in humans, we don’t necessarily know exactly what the dose curve looks like for duration of fasting to physiologic output of desired consequence.” —Peter Attia