#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley
Cortisol and cross-pollination
Cortisol is a hormone I’ve been paying a lot more attention to of late.
Fast-breaking without glucose spiking
As I’m coming off of a week of fasting and heading into a week of a ketogenic diet, the timing seems right to address the question of how I break a longer-term fast and the responses that some people get.
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
Metformin and exercise
If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.
#41 – Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights
“You have this unique population of [type 1 diabetics] where you can see the insulin that goes into them, and you can see it’s direct impact on weight gain. . . and they’re at risk for cardiovascular illness. And to me that just says that there’s something about the Standard American Diet that’s making us sick. And ultimately we will all be at risk for cardiovascular disease.” —Jake Kushner
#30 – Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?
“The standard of care should never have been written in granite. It should be flexible. If you have something else that comes along that might be better, you’d think there would be enthusiasm.” —Tom Seyfried
#09 – David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?
“It’s the happenstance of science that makes it interesting.” —David Sabatini
Is Type 2 Diabetes Reversible at Scale?
If you’re reading this, you probably know that I’m obsessed with longevity.