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Metformin and exercise
If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.
Ketones, fasting, and muscle loss
I read an interesting article authored by my friend Dom D’Agostino and his colleagues on the anti-catabolic effects of ketone bodies in skeletal muscle.
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
“I pay more attention today to stress than anything else.” —Nav Chandel
Easter Island, inflammation, and ask me anything
The implications of the story are frightening, but kudos to the correspondent and photographer that put this story together.
#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
“Use the correct terminology with everything.” –Tom Dayspring
#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system
“Neurons like to be tickled, not bludgeoned.” —Rob Lustig
#11 – AMA #2: the Nothingburger — results from Peter’s week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting
“Not everything that can be counted counts, and not everything that counts can be counted.” —William Bruce Cameron
#06 – D.A. Wallach: music, medicine, longevity, and disruptive technologies
“The way that anything looks before we understand it is pretty imposing . . . when we have breakthroughs, they feel like an enormous relief, because something that seemed really complicated becomes really simple.” —D.A. Wallach
#03 – Ron Krauss, M.D.: a deep dive into heart disease
“Anybody interested in this field should probably understand the origins.” —Ron Krauss
When does heart disease begin (and what this tells us about prevention)?
Before I get into this post I want to lay a few things out.