#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
Metformin and exercise – déjà vu all over again?
Metformin blunts muscle hypertrophy in response to progressive resistance training
Can you maintain muscle during fasting?
But in the short-term (at least up to a week for most people), I believe you can maintain muscle mass while fasting, particularly if you’re resistance training.
Targeting aging
Given that “TOR” is literally “Target of Rapamycin,” it’s no surprise that rapamycin may increase longevity.
Wanna know what keeps me up at night?
Unfortunately, the answer is: We have no clue what the best protocol is for intermittent fasting (fasting that is done periodically, and not to be confused with time restricted feeding).
#09 – David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?
“It’s the happenstance of science that makes it interesting.” —David Sabatini
Robin Williams, Globalism on the brink, rapamycin and lifespan
I think seeing a picture of Robin this week on Lance Armstrong’s Instagram page got me thinking about him. I still remember exactly where I was the moment I found out about his death.
Back to the future
The most interesting paper I (re-)read this week was “Twenty-five years of mTOR: Uncovering the link from nutrients to growth,” by my buddy David Sabatini.