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Nutritional biochemistry – calorie restriction

Why is maintaining weight loss more challenging than losing weight?

This video clip is taken from Podcast #197 — The science of obesity & how to improve nutritional epidemiology with David…

#197 – The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.

How much does obesity kill you because it stigmatizes you and it creates some stress?”  —David Allison

#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules

“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad

#167 – Gary Taubes: Bad science and challenging the conventional wisdom of obesity

Doing a background analysis is the hard, relentless, rigorous grunt work of science. It’s endless and thankless, because if you do it right, all you’ll do is prove that you were wrong all along.” —Gary Taubes

#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman

#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico

“Skeletal muscles are the greatest reservoir that you have for glucose disposal.” —Peter Attia

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

#92 – AMA #12: Strategies for longevity (which don’t require a doctor)

“If you are interested in longevity, if you are interested in playing with your great grandkids, you want to prioritize muscle mass. Never in the history of civilization has a 90 year old said, ‘I wish I had less muscle.’” —Peter Attia

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