#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David
#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley
#109 – John Dudley: The beauty in archery, the love of practice, and a model system for life
“It’s a necessity, not only to archery, but to any sport, for people to recognize the fact that the fundamentals are what makes people good at things.” — John Dudley
#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
“I think once people enter that seventh and eighth decade, if they haven’t done a lot of consistent preparatory work in the decades prior, it’s alarming how quickly things go south.” —Peter Attia
#107 – John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons
“Society is based on trust. When trust evaporates, society begins to fray.” — John Barry
#106 – Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism
“All of that makes me very optimistic that we will be able to meet the challenge of this virus without putting any of our hospitals into crisis, that this is going to be a severe challenge for this country, but it’s not something that that is going to break the country.” — Dr. Amesh Adalja, referring to some lesser discussed positive trends
#105 – Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted
“The virus isn’t plotting against us. It doesn’t have intelligence. It’s invisible. In order to unite, we have to recognize our shared humanity.” — Paul Conti
#104 – COVID-19 for kids with Olivia Attia
“The underlying theme to how we got here is we didn’t really do the things we needed to do before it was too late.” — Peter Attia
#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held
“I reserve metformin prescriptions for patients who obviously are in need of it from the standpoint of glucose and insulin regulation, but I don’t view it really as a pro longevity agent yet.” — Peter Attia