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#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick
#122 – Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health
“Change happens gradually, then suddenly.” — Lori Gottlieb
#121 – Azra Raza, M.D.: Why we’re losing the war on cancer
“We are living in an era of the most sophisticated technological advances possible, and yet the treatment of cancer is paleolithic.” — Azra Raza
#119 – Terry Real: Breaking the cycle of shame, anger, and depression
“Family pathology rolls from generation to generation like a fire in the woods taking down everything in its path until one person, in one generation, has the courage to turn and face the flames. That person brings peace to his ancestors and spares the children that follow.” — Terry Real
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David
#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley
#109 – John Dudley: The beauty in archery, the love of practice, and a model system for life
“It’s a necessity, not only to archery, but to any sport, for people to recognize the fact that the fundamentals are what makes people good at things.” — John Dudley
#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
“I think once people enter that seventh and eighth decade, if they haven’t done a lot of consistent preparatory work in the decades prior, it’s alarming how quickly things go south.” —Peter Attia