Mental health Psilocybin for depression? The psychedelic drug goes head-to-head with Lexapro in a recent trial Understanding science #143 – John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it “We need to defend our method. We need to defend our principles. We need to defend the honesty of science in trying to communicate it rather than building exaggerated promises or narratives that are not realistic.” —John Ioannidis Understanding science Studying Studies: Part V – power and significance Studies can be statistically powerful and significant, but practically weak and meaningless (and vice versa).