Learn more about Peter Attia’s digital program
#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more
“One of the most important things to understand when you are using some sort of intervention is, do you have a biomarker to know if you’re doing it correctly?” —Peter Attia
#251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more
“The bottom line here is the earlier you were diagnosed with type 2 diabetes, the higher your risk of dementia.” —Peter Attia
Vitamin D(éjà vu): new study, same old problems
For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D, and if it doesn’t, then the treatment and placebo groups are effectively identical. So did the researchers achieve a difference in vitamin D levels over the course of the study?
Does vitamin D deficiency raise COVID-19 risk?
Expectations for vitamin D and COVID-19
#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives
“Believe it or not, there are 46 million Americans with Alzheimer’s disease in their brain right now, but no symptoms.” — Richard Isaacson
Randomized controlled trials: when the gold standard leaves you with fool’s gold
If I told you that I read a randomized double-blinded placebo-controlled trial conducted over 5 years and carried out in over 18,000 participants, is there any scenario under which you would not believe it to be an excellent trial?
Did a recent study show we can reverse aging?
I dig a little deeper into the recent study that suggests (to some) the answer is yes.
Can you reverse your biological age?
I realize it may seem like Groundhog Day for you to see more prose from me about how to think about studies rather than the tactical bits we think we can immediately extract and employ from them. Just remember, it’s better to learn how to fish than to be given … you get it.
#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
“The way we raise our kids early on might actually set a pattern for how much of an accelerated life, or how much of a stressed out nervous system they might have later on. . . a lot of the behavioral patterns that we’re instilling in our kids are kind of setting the foundation for insulin resistance and inflammation early on.” —Ronesh Sinha
#62 – Keith Flaherty, M.D.: Deep dive into cancer— History of oncology, novel approaches to treatment, and the exciting and hopeful future
“We can’t keep hitting the same pillar and expect that we’re going to cure cancer. . .we need the activators of the immune system, we need the inhibitors of the activated oncogenes, we need the drugs that target epigenetic regulators, and we need the metabolic switch regulators.” — Keith Flaherty