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#189 – COVID Part 1: Current state of affairs, Omicron, and a search for the end game
“Where’s the humility? People are hungry for honesty right now.” —Marty Makary
#169 – Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation
“There is no smoking gun per se. What there is is smoke coming out of a lot of windows. … There is enough smoke coming out of enough windows that we cannot take the lab leak hypothesis off the table, and so for me, the most credible people on this, they’re not saying it was a lab leak. What they’re saying is, ‘Why can’t we have a full investigation?’” —Katherine Eban
#161 – AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action
“It’s so fascinating to me frankly that one molecule found in nature can be so potent. It’s hard to imagine you could engineer a drug to do this.” —Peter Attia
#160 – Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants
“If you ask me the question, ‘What do I fear most about this whole pandemic?’ it’s actually not the variants. … It’s that there would be a significant percentage of the population that is going to choose not to vaccinate so much so that we can’t get to that 80+% of population immunity we need to slow this virus.” —Paul Offit
#159 – Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs
“What started out as an anti-vaccine movement is now a movement against any kind of public health intervention and demonizing scientists and basically calling us the boogeyman.” —Peter Hotez
#143 – John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
“We need to defend our method. We need to defend our principles. We need to defend the honesty of science in trying to communicate it rather than building exaggerated promises or narratives that are not realistic.” —John Ioannidis
#137 – Paul Offit, M.D.: An expert perspective on COVID-19 vaccines
“When people talk to me about how nervous they are that antibodies are fading, I’m not sure you should be nervous about it yet. Let’s wait to see what happens as we move forward with these vaccines.” — Paul Offit
#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick
#117 – Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19
“There’s really no evidence so far that says this virus has changed in a way that makes it unlikely a vaccine will work, unlikely that a previous infection will protect you from a second infection–there may be reasons why it won’t, but it won’t be because the virus is changing.” — Stanley Perlman
#115 – David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19
“As we stand here with the coronavirus epidemic three months old, I think we should have faith that science will find a solution to this.” — David Watkins