#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.
“[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein
#271 – AMA #51: Understanding and improving your metabolic health
“Zone 2 output is arguably the most important functional test we have of metabolic health.” —Peter Attia
#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers
“This paper basically addresses how our beliefs about the drugs we take impacts how they affect us at a real level, not just at a subjective level, but at a biological level.” —Andrew Huberman
#269 – Good vs. bad science: how to read and understand scientific studies
“I think epidemiology has a place, but I think the pendulum has swung a little too far, and it has been asserted as being more valuable than I think it probably is.” —Peter Attia
#268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D.
“There are literally tens of thousands of genetic variants in your genome, and what they mean and whether or not they do anything whatsoever is hard to know.” —Wendy Chung
#267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D.
“Early detection is going to allow our same toolbox of drugs to be massively more effective.” —Keith Flaherty
#266 – AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more
“With how much uncertainty there is in genetic testing, I just think everybody needs to be thoughtful about it before they do it.” —Peter Attia
#265 – Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman
“Part of living a meaningful life is to be conscious of that fact that we don’t get all the time we would wish to have.” —Oliver Burkeman
#264 ‒ Hip, knee, ankle, and foot: diagnosis, treatment, and surgery of the lower extremities | Adam Cohen, M.D.
“Just like we talked about in the shoulder, and the knee, and the hip, any mechanical trauma to the joint puts you at increased risk for arthritis of that joint.” —Adam Cohen
#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.
“If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins