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Podcast

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Podcast

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein

COVID-19

#117 – Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

“There’s really no evidence so far that says this virus has changed in a way that makes it unlikely a vaccine will work, unlikely that a previous infection will protect you from a second infection–there may be reasons why it won’t, but it won’t be because the virus is changing.” — Stanley Perlman

Ketosis

#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino

COVID-19

#115 – David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

“As we stand here with the coronavirus epidemic three months old, I think we should have faith that science will find a solution to this.” — David Watkins

Fasting

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

Podcast

#113: Normative errors — a conversation with my daughter about current events

In this episode, I sit down with my daughter to discuss the brutal death of George Floyd, and the aftermath we are watching unfold. Though I have no expertise in race relations, law enforcement, or police brutality, I do have some knowledge in the training of physicians, and it is that training of doctors that…

Aging

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David

Diseases

#111 – AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity

“Metabolic health really matters. It is the common thread that links all of these chronic diseases.” — Peter Attia

Diseases

#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley

Mental models

#109 – John Dudley: The beauty in archery, the love of practice, and a model system for life

“It’s a necessity, not only to archery, but to any sport, for people to recognize the fact that the fundamentals are what makes people good at things.” — John Dudley

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