#176 – AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity
“If you have the aspiration of kicking ass when you’re 85, you can’t afford to be average when you’re 50.” —Peter Attia
#175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process
“I don’t think I will ever understand aging fully. And I don’t think the field will. … But I also believe that we don’t have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein
#174 – Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learned
“I think every American was profoundly affected in one way or another. For one thing, there was this sense of invulnerability … that was so punctured. It was so disillusioning, that we’re a regular country and we’re vulnerable, and that was shattering. And I don’t think anybody who was cognizant at that age, I don’t think anybody walked away feeling the same” — Lawrence Wright
#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions
“Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia
#172 – Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotions
“I don’t fundamentally believe that one can know oneself without knowing oneself in relationship to others.” —Esther Perel
#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules
“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad
#170 – AMA #25: Navigating the complexities and nuances of cancer screening
“We screen often, we screen early, and we screen aggressively.” —Peter Attia
#169 – Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation
“There is no smoking gun per se. What there is is smoke coming out of a lot of windows. … There is enough smoke coming out of enough windows that we cannot take the lab leak hypothesis off the table, and so for me, the most credible people on this, they’re not saying it was a lab leak. What they’re saying is, ‘Why can’t we have a full investigation?’” —Katherine Eban
#168 – Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine
“The world will always need people who are going to do what they love. But know when enough is enough. More is not always better in terms of consuming or just achievement. Be disciplined about doing less.” —Hugh Jackman
#167 – Gary Taubes: Bad science and challenging the conventional wisdom of obesity
“Doing a background analysis is the hard, relentless, rigorous grunt work of science. It’s endless and thankless, because if you do it right, all you’ll do is prove that you were wrong all along.” —Gary Taubes