#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM
“One of the most humbling things about this job is when I meet the children or the adult patients who has had this device change their life . . . it’s really why we come to work every day, what keeps us going.” —Kevin Sayer
#53 – AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more
“Time is the only truly finite resource that we have. It is also the only unifying, equalizing resource. Meaning, no matter how much wealth or smarts or whatever you have, we are all stuck with the same disappearing thing.” — Peter Attia
#52 – Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone – two topics that are surprising interrelated
“Primary prevention is still very much art and not science and probably will be for our lifetime so we’ll have to get used to that.” —Ethan Weiss
The Ayrton Senna Episode (re-release): Celebrating the greatest driver in Formula 1 history and the cautionary tales of driven individuals
To celebrate the life of the legendary Formula 1 driver Ayrton Senna, 25 years to the day of his tragic death, we are re-releasing this bonus episode. In this episode, Peter and med school colleague (and brilliant psychiatrist) Paul Conti reminisce on their favorite moments in Formula 1 history, their deep admiration for the late…
#51 – Robert Sapolsky, Ph.D.: The pervasive effect of stress – is it killing you?
“The [stress response] system has been serving vertebrates, doing a lot of help for them for an awful long time, and it’s only been a very recent modification to instead secrete [cortisol] in response to thinking about taxes.” —Robert Sapolsky
#50 – AMA #5: calcium scores, centenarian olympics, exercise, muscle glycogen, keto, and more
“We’re really talking a completely new model, which is actually forcing your way to become a centenarian rather than just sort of gliding your way into it and therefore, I think it’s going to require much more deliberate attention around what your mind and body are doing at that point and time.” — Peter Attia
#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleep
“Lack of sleep is like a broken water pipe in your home. It will leak down into every nook and cranny of your physiology.” —Matthew Walker
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)
“If there is one central, common pathway through which we can understand almost all aspects of the deleterious impact of insufficient sleep, it is…an excessive leaning on the fight or flight branch of the nervous system.” — Matthew Walker
#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer’s risk, mental health, memory consolidation, and more
“I think that sleep may be one of the most significant lifestyle factors that determines your risk ratio for Alzheimer’s disease.” — Matthew Walker
#46 – Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease – NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more
“People are gonna make a decision to. . . either wait 10 or 20 years until we know something better, or you take the position that you’re going to tinker. And if you’re going to tinker, you’re a lot more successful if you have a working model of what’s going on than if you don’t.” —Chris Masterjohn