Understanding science

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Research Worth Sharing, April 2026 Edition

Other tactics, tools, & treatments

AMA

Aging clocks—what they measure, how they work, and their clinical and real-world relevance

Ep. #386
Medications & supplements

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Updated cardiovascular guidelines—statin use in patients as young as 30

Nutrition

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Thinking in trade-offs: a necessary antidote to diet tribalism

Risks

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Protect the eyes, protect the brain—a potentially simple lever for dementia risk

Ask Me Anything (AMA)

AMA

Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

Ep. #385 (AMA #82)
Understanding science

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When sophisticated models meet questionable premises

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Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention

Ep. #384
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An intriguing case of “exceptional resilience” against dementia

Longevity

AMA

Biological aging tests, longevity training, emerging therapies, GLP-1 RAs, sun exposure, and more

Ep. #383 (AMA #81)
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A failed endpoint is not a failed technology

Longevity

AMA

Longevity optimization through strength benchmarks, VO₂ max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and more

Ep. #382 (AMA #80)
Risks

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Does lowering cholesterol harm the brain?

Medications & supplements

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GLP-1 Drugs Fail to Slow Cognitive Decline in Alzheimer’s Disease

Medications & supplements

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Metformin misses the mark?

Medications & supplements

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Navigating the complex relationship between statins, GLP-1, and glycemic control

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The absence of atherosclerosis is not an excuse to ignore heart attack symptoms—especially for women

Nutrition

Guest Episode

The seed oil debate: are they uniquely harmful relative to other dietary fats?

Ep. #380 with Layne Norton, Ph.D.
Exercise

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Why this exercise study isn’t answering the question you think it is

Exercise

AMA

A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence

Ep. #379 (AMA #79)
Risks

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Pitting facts against sensationalism regarding the role of LDL cholesterol in ASCVD

Exercise

Guest Episode

Women’s health and performance: how training, nutrition, and hormones interact across life stages

Ep. #378 with Abbie Smith-Ryan, Ph.D.
Understanding science

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Oldies-But-Goodies: January 2026 Edition

Other tactics, tools, & treatments

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Using “atomic habits” to reach your health goals