Risks

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients.

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

Nutrition

Free Article

Oldies-But-Goodies, December 2024 Edition

Understanding science

Free Article

Oldies-But-Goodies, December 2024 Edition

Risks

Free Article

Shingles and Brain Health: An Emerging Link or Healthy User Bias?

Exercise

Free Article

Calming the concern over exercise duration and coronary artery calcification

Risks

QPS

Peter’s key takeaways on bone health, calorie restriction, gene editing and more

Ep. #325

Longevity

Free Article

Radical extension of the human lifespan, science fiction or reality?

Nutrition

Guest Episode

Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health

Ep. #324 with Eric Ravussin, Ph.D.

Risks

Guest Episode

CRISPR and the future of gene editing

Ep. #323 with Feng Zhang

Exercise

Guest Episode

Bone health for life

Ep. #322 with Belinda Beck, Ph.D.

Mental & Emotional Health

Guest Episode

Dopamine and addiction: navigating pleasure, pain, and the path to recovery

Ep. #321 with Anna Lembke, M.D.

Medications & supplements

AMA

New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro)

Ep. #320 (AMA #64)

Understanding science

QPS

Peter's key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism

Ep. #319

Exercise

Free Article

High-intensity interval training and cognitive function in older adults: promising but limited findings

Other tactics, tools, & treatments

Free Article

Could plasma protein levels be a surrogate for VO2 max testing as a measure of cardiorespiratory fitness?

Understanding science

Guest Episode

Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation

Ep. #317 with Marty Makary, M.D., M.P.H.

Risks

Free Article

A new blood test doesn’t change the game for colorectal cancer screening

Nutrition

Free Article

Back on the merry-go-round of bad science regarding meat consumption

Nutrition

Guest Episode

Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards

Ep. #314 with David Allison, Ph.D.

Risks

Free Article

Coronary atherosclerosis is a silent killer, but we have tools to stop it

Nutrition

AMA

Protein’s impact on appetite and weight management, and uric acid's link to disease and how to manage levels

Ep. #313 (AMA #62)

Longevity

Podcast Episode

Longevity 101

Ep. #311

Medications & supplements

Free Article

Does pharmacological treatment for ADHD increase risk of cardiovascular disease?

Risks

Guest Episode

The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy

Ep. #310 with Ted Schaeffer, M.D., Ph.D.

Risks

Free Article

Don’t underestimate the importance of oral health