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Risks

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

Risks

Peter on the four horsemen of chronic disease

This audio clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of…

#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape

“If you’re taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that’s obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia

#319 ‒ Peter’s key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #2

In humans, klotho is indeed a longevity gene. More klotho from the gene means longer life, better cognition. Take it away, shorter life, worse cognition.” —Peter Attia

High-intensity interval training and cognitive function in older adults: promising but limited findings

A new study indicates that HIIT may help delay or even reverse age-related declines in memory and learning, but this exercise modality remains just one aspect of a well-balanced regimen.

Could plasma protein levels be a surrogate for VO2 max testing as a measure of cardiorespiratory fitness?

A proteomics model may provide an alternative method for estimating risk of mortality and chronic disease

A new blood test doesn’t change the game for colorectal cancer screening

How a new cell-free DNA test stacks up against other available options

Back on the merry-go-round of bad science regarding meat consumption

A new observational study has reported positive associations between meat intake and type 2 diabetes risk, but let’s repeat: correlation is not causation.

Coronary atherosclerosis is a silent killer, but we have tools to stop it

A new study reveals that the prevalence of atherosclerosis is alarmingly high among asymptomatic adults classified as “low risk” and underscores the importance of lipid-lowering therapies for avoiding atherosclerosis progression and mortality

#313 – AMA #62: Protein’s impact on appetite and weight management, and uric acid’s link to disease and how to manage levels

The body responds in pretty significant ways to alterations in protein availability.” —Peter Attia

#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

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