Category

Cardiovascular Disease

One of the scariest things about heart disease is that it is often a silent killer, with few to no outward symptoms. As one of my medical school professors liked to point out, the most common “presentation” of the disease is a sudden, fatal heart attack. You know the patient has heart disease because he has just died from it.

And while mortality rates from those first, surprise heart attacks have dropped significantly thanks to improvements in basic cardiac life support and time-sensitive interventions, such attacks are still fatal roughly 1/3 of the time.

Below is a collection of past articles and podcasts related to heart disease prevention, atherosclerosis, coronary disease, cholesterol, apoB, and more.

“Not everybody dies from atherosclerosis, but… everybody dies with it.” — Peter Attia

“HDL cholesterol itself is not directly and causally protective against atherosclerotic cardiovascular disease.” —Dan Rader

“ApoB is a necessary, though not sufficient, factor in the development of ASCVD which means the more you lower it, the more you lower risk. Full stop.” —Peter Attia

“How we live the first half of our lives really influences our freedom for morbidity and mortality the second half of our lives.” —Erin Michos

statins and Lp(a)

Statin therapy is known to raise Lp(a) particle concentration in some patients, but how does this impact the overall effect of these medications on ASCVD risk?

“Not everybody dies from atherosclerosis, but… everybody dies with it.” —Peter Attia

PCSK9 inhibitors

A recent case study shines light on why some individuals are resistant to PCSK9 inhibitors.

This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18,…

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer,…

Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.

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