Category

Cardiovascular Disease

One of the scariest things about heart disease is that it is often a silent killer, with few to no outward symptoms. As one of my medical school professors liked to point out, the most common “presentation” of the disease is a sudden, fatal heart attack. You know the patient has heart disease because he has just died from it.

And while mortality rates from those first, surprise heart attacks have dropped significantly thanks to improvements in basic cardiac life support and time-sensitive interventions, such attacks are still fatal roughly 1/3 of the time.

Below is a collection of past articles and podcasts related to heart disease prevention, atherosclerosis, coronary disease, cholesterol, apoB, and more.

Cardiovascular Disease

#203 – AMA #34: What Causes Heart Disease?

Not everybody dies from atherosclerosis, but… everybody dies with it.” — Peter Attia

Where a study on metformin and cardiovascular disease fell short – and what it can teach us

An investigation on metformin, diabetes, lipid biology, and cardiovascular disease offered little insight on any of these topics, but it illustrates common problems in scientific research

Statins: effectiveness, safety, and common myths on their role in ASCVD prevention

A review of the evidence for statins in combating heart disease

A case study on the importance of taking charge of one’s own health

The personal story of a podcast listener who sought to gain a better picture of his cardiovascular health – and who saved his own life as a result.

#258 – AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure

If you care about your brain, if you care about your heart and if you care about your kidneys, you need low blood pressure. I think we can say that as confidently as we can say almost anything in medicine.” —Peter Attia

#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

“One of the things that is so dangerous about this disorder is that the plaque that you get in FH is a soft plaque.” —John Kastelein

#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D.

If everybody got truly optimal medical therapy, if we didn’t have barriers to using all these tools in everybody, I think this disease would largely be controlled.” —Ethan Weiss

More hype than substance: erythritol and cardiovascular risk

A newly-published study caught public attention by reporting an association between the common sweetener erythritol and increased risk of heart attack and stroke, but there’s more to the story.

#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.

HDL cholesterol itself is not directly and causally protective against atherosclerotic cardiovascular disease.” —Dan Rader

#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease

ApoB is a necessary, though not sufficient, factor in the development of ASCVD which means the more you lower it, the more you lower risk. Full stop.” —Peter Attia

#230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D.

How we live the first half of our lives really influences our freedom for morbidity and mortality the second half of our lives.” —Erin Michos

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