Category

Cardiovascular Disease

One of the scariest things about heart disease is that it is often a silent killer, with few to no outward symptoms. As one of my medical school professors liked to point out, the most common “presentation” of the disease is a sudden, fatal heart attack. You know the patient has heart disease because he has just died from it.

And while mortality rates from those first, surprise heart attacks have dropped significantly thanks to improvements in basic cardiac life support and time-sensitive interventions, such attacks are still fatal roughly 1/3 of the time.

Below is a collection of past articles and podcasts related to heart disease prevention, atherosclerosis, coronary disease, cholesterol, apoB, and more.

Cardiovascular Disease

#203 – AMA #34: What Causes Heart Disease?

Not everybody dies from atherosclerosis, but… everybody dies with it.” — Peter Attia

First Case of Human PCSK9 Gene-Editing

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

The connection between sleep and heart disease

This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer,…

Cumulative effects of LDL-C reduction in mitigating cardiovascular risk

Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.

Lp(a) and CVD risk & clinical tests to measure Lp(a)

This video clip is from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D., originally…

Can cocoa help prevent cardiovascular death?

A recent study explored whether supplementation with the beneficial compounds in cocoa could have a clinically-relevant effect on ASCVD.

Peter’s approach to managing patients with high Lp(a)

This video is a clip from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D.,…

#210 – Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

I think we should advise people to measure Lp(a); that would be a gigantic step.” —Benoît Arsenault

For triglycerides, “normal” may not be “optimal”

How do triglyceride levels relate to cardiovascular risk?

Intro to lipids & lipoproteins: why there is no ‘bad’ or ‘good’ cholesterol

I recently posted on Twitter about my frustration with the way the press writes about “good” and “bad” cholesterol, and…

Peter on the four horsemen of chronic disease

This audio clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of…

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