Category

Cardiovascular Disease

One of the scariest things about heart disease is that it is often a silent killer, with few to no outward symptoms. As one of my medical school professors liked to point out, the most common “presentation” of the disease is a sudden, fatal heart attack. You know the patient has heart disease because he has just died from it.

And while mortality rates from those first, surprise heart attacks have dropped significantly thanks to improvements in basic cardiac life support and time-sensitive interventions, such attacks are still fatal roughly 1/3 of the time.

Below is a collection of past articles and podcasts related to heart disease prevention, atherosclerosis, coronary disease, cholesterol, apoB, and more.

statins and Lp(a)

Reassuring new data on statin-induced Lp(a) elevation

Statin therapy is known to raise Lp(a) particle concentration in some patients, but how does this impact the overall effect of these medications on ASCVD risk?

#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB

Not everybody dies from atherosclerosis, but… everybody dies with it.”  —Peter Attia

PCSK9 inhibitors

The genetics of PCSK9i nonresponders

A recent case study shines light on why some individuals are resistant to PCSK9 inhibitors. 

Heart Disease: Labs & Diagnostic Tests

This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18,…

First Case of Human PCSK9 Gene-Editing

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

The connection between sleep and heart disease

This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer,…

Cumulative effects of LDL-C reduction in mitigating cardiovascular risk

Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.

Lp(a) and CVD risk & clinical tests to measure Lp(a)

This video clip is from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D., originally…

Can cocoa help prevent cardiovascular death?

A recent study explored whether supplementation with the beneficial compounds in cocoa could have a clinically-relevant effect on ASCVD.

Peter’s approach to managing patients with high Lp(a)

This video is a clip from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D.,…

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