Cholesterol is one of the most important molecules in the human body and is most commonly known for the role it plays in atherosclerotic cardiovascular disease (ASCVD) — the number one killer in the developed world.

Below is a collection of content that goes into great depth about cholesterol, the role cholesterol plays with respect to heart disease, why there is no ‘good’ or ‘bad’ cholesterol, and why apoB is actually a superior metric for assessing CVD risk over cholesterol.


Intro to lipids & lipoproteins: why there is no ‘bad’ or ‘good’ cholesterol

I recently posted on Twitter about my frustration with the way the press writes about “good” and “bad” cholesterol, and…

“The cholesterol paradox”: a catchy phrase for an idea with no substance

A recent study reported that hypercholesterolemia is associated with reduced mortality, but it falls short of upsetting conventional wisdom

PCSK9 inhibitors

The genetics of PCSK9i nonresponders

A recent case study shines light on why some individuals are resistant to PCSK9 inhibitors. 

Heart Disease: Labs & Diagnostic Tests

This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18,…

First Case of Human PCSK9 Gene-Editing

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

Cumulative effects of LDL-C reduction in mitigating cardiovascular risk

Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.

Lp(a) and CVD risk & clinical tests to measure Lp(a)

This video clip is from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D., originally…

Peter’s approach to managing patients with high Lp(a)

This video is a clip from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D.,…

#210 – Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

I think we should advise people to measure Lp(a); that would be a gigantic step.” —Benoît Arsenault

For triglycerides, “normal” may not be “optimal”

How do triglyceride levels relate to cardiovascular risk?

#203 – AMA #34: What Causes Heart Disease?

Not everybody dies from atherosclerosis, but… everybody dies with it.” — Peter Attia

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