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Fast-breaking without glucose spiking

As I’m coming off of a week of fasting and heading into a week of a ketogenic diet, the timing seems right to address the question of how I break a longer-term fast and the responses that some people get.

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Is there an optimal window of time-restricted feeding?

Breakfast like a king, lunch like a prince, and dine like a pauper?

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Metformin and exercise

If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.

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Skipping breakfast

Nota bene: I was pretty pissed off when I wrote this, but don’t let my annoyance detract from the message. Bad science is an abomination. Incompetent news reporting on bad science is worse.

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My view on wearables

What gets measured gets managed?

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Driving while distracted

Whether you drive an automatic or manual, here’s a game of driving that I like to play in order to stay hypervigilant, and I encourage you to play it: Imagine that someone on the road is trying to kill you today.

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The mouse trap: lost in translation?

“The great majority of how we understand disease, and attempt to cure it,” writes Engber, “derives from a couple of rodents.” About 4/5ths of all animal studies reported in biomedical research papers from 1950-2010 were done in rodents (59% in mice, 18% in rats).

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Red meat, cancer, push-ups, and CVD

Groundhog Day (GD) came and went last month — and sure enough — 2019 has already brought a bounty of emails and Tweets from concerned folks wondering if red meat is going to kill them (again).

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Ketones, fasting, and muscle loss

I read an interesting article authored by my friend Dom D’Agostino and his colleagues on the anti-catabolic effects of ketone bodies in skeletal muscle.

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How to make better decisions

Ironically, this might be my confirmation bias talking, but in my interview with Sid Mukherjee, he referred to Bayesian logic as perhaps one of the great neglected ideas in medicine, and in the world in general.

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