Category

Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

Preventing Chronic Disease

Peter on the four horsemen of chronic disease

This audio clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of…

First Case of Human PCSK9 Gene-Editing

Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.

#216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

“My big hope is that we’re going to be able to have some combination of directed, metabolic immune supplements and diet that really work with therapy to treat cancer.” —Josh Rabinowitz

Alzheimer’s disease — what labs can tell you about your risk

This clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity,…

Why does Alzheimer’s disease affect more women than men?

This clip is from episode #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives,…

The connection between sleep and Alzheimer’s disease

This audio clip is from episode #47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of…

The connection between sleep and heart disease

This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer,…

Fighting cancer and improving immune function with sleep

This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease,…

Why sleep is the best insurance policy for lifespan and healthspan

This video clip is from episode #58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping…

#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D.

I was frustrated by not being able to diagnose a recurrence earlier.” —Max Diehn

Cumulative effects of LDL-C reduction in mitigating cardiovascular risk

Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.

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