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One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients.

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

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Free Article

Vaginal estrogen: a potentially life-saving therapy

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Guest Episode

Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment

Ep. #406 with Brian Grosberg, M.D.

Medications & supplements

Premium Article

The expanding reach of GLP-1–based therapies

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AMA

Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease

Ep. #405 (AMA #88)

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Free Article

Gum recession: a common oral health issue that often goes unnoticed

Mental & Emotional Health

Guest Episode

Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies

Ep. #404 with Linus Abrams, M.D.

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Free Article

Multifactorial trials: taking apart the kitchen sink

Medications & supplements

Podcast Episode

Peptides: separating scientific promise from marketing hype

Ep. #403

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Free Article

Does protein restriction still make sense in modern kidney care?

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Guest Episode

NMR blood analysis: how heart disease risk, insulin resistance, inflammation, and mortality risk can be assessed from a single blood sample

Ep. #402 with Jim Otvos, Ph.D.

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Free Article

Zero coronary calcium does not mean zero cardiovascular risk

Understanding science

Podcast Episode

How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare

Ep. #401

Medications & supplements

Free Article

Lithium and Alzheimer’s disease: what to weave of this LATTICE?

Nutrition

Premium Article

Should you choose organic food?

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AMA

Environmental pollution and longevity: air pollution, noise, light, EMFs, and practical strategies to mitigate health risks

Ep. #400 (AMA #87)

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Guest Episode

The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape

Ep. #399 with Gayatri Devi, M.D.

Sleep

Free Article

Does losing sleep mean losing lifespan?

Exercise

Podcast Episode

Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (AMA #71 rebroadcast)

Medications & supplements

Free Article

Metformin and cancer: active surveillance needed

Medications & supplements

AMA

GLP-1 RAs and muscle loss: new data, better questions, and how to preserve muscle during weight loss

Ep. #398 (AMA #86)

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Free Article

The trouble with “good cholesterol”

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Premium Article

Lung cancer screening in never-smokers: the data

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Guest Episode

Endometriosis and adenomyosis: diagnosis, fertility, reproductive aging, and emerging treatments

Ep. #397 with Renato Tomioka, M.D., Ph.D.

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Podcast Episode

Breast cancer screening: understanding risk, deciding when to start and how often to screen, and choosing the right imaging strategy

Ep. #396