Category

Metabolic health

One way to think about metabolic disease is as a disorder in fuel processing. Whether we’re talking about hyperinsulinemia or type 2 diabetes, the fundamental problem is that the body is not doing a good job storing and accessing fuel.

I think of the three most deadly chronic diseasesheart disease, cancer, and dementia — as pillars all resting on the foundation of metabolic disease. While complications from metabolic disease often do not directly lead to death, the indirect cost is staggering. Each of the other major pillars of chronic disease is exacerbated and amplified by metabolic dysregulation.

Metabolic disease typically exists on a continuum — progressing from hyperinsulinemia, to insulin resistance, to non-alcoholic fatty liver disease, all the way to type 2 diabetes — and tends to cluster with five signs which make up the diagnostic criteria for Metabolic Syndrome, including: high blood pressure, elevated triglycerides, elevated blood glucose, truncal obesity, and low HDL-cholesterol.

The following is a collection of content that dives deeper into the topic of metabolic health, discussing specific strategies for prevention and treatment.

Risks

How metabolic health impacts your ‘optimal’ diet

This audio clip is from “Ask Me Anything” (AMA) episode #36 — all things fruits and vegetables, originally released on June 20,…

#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape

“If you’re taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that’s obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia

Back on the merry-go-round of bad science regarding meat consumption

A new observational study has reported positive associations between meat intake and type 2 diabetes risk, but let’s repeat: correlation is not causation.

#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more

I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia

#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia

Do high protein diets increase cancer risk?

Is there any merit to the idea that consuming more protein increases one’s risk of developing or dying from cancer?

#302 – Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage MAFLD and liver disease | Julia Wattacheril, M.D., M.P.H.

The average person you’re seeing with MASLD is much more at risk for cardiovascular-related outcomes and malignancy-related outcomes from their metabolic health than they are for liver-related risks.” —Julia Wattacheril

#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia

Does the timing of sleep loss during the night impact subsequent negative metabolic effects?

A recent study claims that late-night sleep loss is more damaging than early-night sleep loss, but the data leave ample room for doubt

Does low iron intake change exercise capacity?

A study demonstrates metabolic shifts that occur with and without sufficient iron levels

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