Cognitive Health & Neurodegenerative Disease

Patients often tell me they would like to live as long as they reasonably can, provided they do not suffer cognitive decline. More often than not, people care less about how long they live and more about how well they live, specifically as it pertains to their brain.

Anyone who has seen a relative suffer from a neurodegenerative disease – such as dementia or Alzheimer’s disease – can no doubt relate to the debilitating nature of these conditions. Unlike heart disease and cancer, which kill directly, the fatal impact of neurodegenerative diseases is often indirect.

While much is still unknown, data suggest that there are indeed things that can be done to ward off one’s risk of developing a neurodegenerative disease. Aside from genetics, the next most common risk factor we see is vascular disease.

The adage “what’s good for the heart is good for the brain” rings true here. Meaning, the factors that increase your risk for atherosclerosis – such as high blood pressure, smoking, and elevated apoB – also increase the risk of dementia.

Below is a collection of past articles and podcasts exploring such tactics. My hope is that this content can serve as helpful resources to dive deeper into this topic as well as support your ongoing longevity journey.

Understanding science

Podcast Episode

How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare

Ep. #401

Medications & supplements

Free Article

Lithium and Alzheimer’s disease: what to weave of this LATTICE?

Risks

Guest Episode

The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape

Ep. #399 with Gayatri Devi, M.D.

Risks

Guest Episode

Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer's disease risk, and the effects of lipid-lowering therapies on brain health

Ep. #395 with Tom Dayspring, M.D.

Risks

Podcast Episode

Genetic testing: when it's valuable, how to choose the right test, and what to do with the results

Ep. #392

Risks

AMA

Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration

Ep. #390 (AMA #84)

Understanding science

Free Article

There is no safe gamble with high LDL cholesterol

Medications & supplements

AMA

Peptides—evaluating the science, safety, and hype in a rapidly growing field

Ep. #387 (AMA #83)

Understanding science

Free Article

Research Worth Sharing, April 2026 Edition

Risks

Free Article

Protect the eyes, protect the brain—a potentially simple lever for dementia risk

Ask Me Anything (AMA)

AMA

Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

Ep. #385 (AMA #82)

Risks

Podcast Episode

Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention

Ep. #384

Risks

Free Article

An intriguing case of “exceptional resilience” against dementia

Longevity

AMA

Biological aging tests, longevity training, emerging therapies, GLP-1 RAs, sun exposure, and more

Ep. #383 (AMA #81)

Longevity

AMA

Longevity optimization through strength benchmarks, VO₂ max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and more

Ep. #382 (AMA #80)

Risks

Premium Article

Does lowering cholesterol harm the brain?

Medications & supplements

Premium Article

GLP-1 Drugs Fail to Slow Cognitive Decline in Alzheimer’s Disease

Nutrition

Guest Episode

The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer’s disease, brain injuries, and more

Ep. #375 with Dominic D’Agostino, Ph.D.

Nutrition

Guest Episode

Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use

Ep. #369 with Rhonda Patrick, Ph.D.

Risks

Free Article

Artificially sweetened beverages for metabolic health: motivation matters

Risks

Free Article

When zero doesn’t mean zero: the limits of coronary calcium in women

Medications & supplements

Free Article

Announcing a special episode on autism and acetaminophen

Risks

Free Article

Cautious optimism over lithium orotate as a treatment for Alzheimer’s disease

Risks

Guest Episode

A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases

Ep. #363 with Edward Chang, M.D.