Category

Insulin Resistance

Insulin resistance (IR) is a topic that’s been of paramount interest in medical research for nearly a century. Insulin is a pancreatic hormone which plays key roles in the metabolism of carbohydrates and fats.

What is Insulin Resistance? When tissues become less responsive to the effects of insulin, the pancreas must produce more and more insulin to maintain glucose homeostasis; this state is the definition of insulin resistance. IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions.

How can we prevent IR from developing, and can it be reversed? IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions, ranging from atherosclerotic cardiovascular disease to Alzheimer’s disease to cancer to fatty liver disease. These threats underscore the critical importance of IR prevention and mitigation (or even reversal) as part of the effort toward extending lifespan and healthspan.

Below is a compilation of podcasts, clips, and articles focused on insulin resistance, what it means, and strategies for prevention and treatment.

Insulin Resistance

Peter Attia on mitigating and reversing insulin resistance with nutrition

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins

“It is worth noting, and this is a very important question, that it does not appear that the effect of statins on insulin resistance is a function of lipids being lowered.” —Peter Attia

The five main tools for managing blood glucose numbers

This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on…

Is natural sugar from fruit just as ‘bad’ as added sugar?

This video clip is taken from episode #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D., originally released on…

Metabolic dysfunction case study and a framework for metabolic health

This audio clip is from “Ask Me Anything” (AMA) episode #15 — Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more, originally…

How metabolic health impacts your ‘optimal’ diet

This audio clip is from “Ask Me Anything” (AMA) episode #36 — all things fruits and vegetables, originally released on June 20,…

Why you should stop drinking sugar

This video clip is taken from  Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D., originally released on…

Can a father’s metformin cause birth defects in his sons?

Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.

How deadly is type 2 diabetes?

Diabetes was only the 8th-leading cause of death in 2020. Can it really be possible that diabetes is so “harmless” relative to the other major chronic diseases, or are the CDC reports only the tip of the iceberg?

Peter Attia on the connection between stress and insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Peter Attia on the role of exercise in mitigating and reversing insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #20, originally released on February 15, 2021. If you’re a member, you…

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