#246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent
“The thing that concerns me the most with these drugs. . .is this drive towards sarcopenia.” —Peter Attia
A recent metformin study casts doubts on longevity indications
A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.
#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito
“Six out of every ten illicit counterfeit pills have enough fentanyl to kill somebody. So if we can take ten pills off the street, we’re potentially saving six lives.” —Anthony Hipolito
Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs”
Clinical trials have generated impressive data on the effects of GLP-1 agonists on body weight and BMI, but how do these drugs perform in terms of body composition?
Antitumor mRNA vaccines are cause for optimism
Moderna recently announced preliminary results of a clinical trial involving a personalized antitumor mRNA vaccine, and despite the knee-jerk uproar, the treatment may prove to be another useful weapon in the battle against cancer
NR supplements: wasted money may not be the only risk with these questionable “anti-aging” drugs
A new study links NR supplementation with accelerated cancer progression in mice.
#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.
“You could time your psychological therapy when your brain is most plastic, most able to learn new things.” —Celia Morgan
Vitamin D(éjà vu): new study, same old problems
For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D, and if it doesn’t, then the treatment and placebo groups are effectively identical. So did the researchers achieve a difference in vitamin D levels over the course of the study?
Can cocoa help prevent cardiovascular death?
A recent study explored whether supplementation with the beneficial compounds in cocoa could have a clinically-relevant effect on ASCVD.
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