#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin
“It’s really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it’s difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein
Is cold exposure beneficial for metabolic health?
A look at whether activating brown fat through cold exposure therapy offers metabolic benefits.
Does regular sauna use provide health benefits?
This audio clip is from AMA #16: Exploring hot and cold therapy, originally released on October 12, 2020.
Can a father’s metformin cause birth defects in his sons?
Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.
#193 – AMA #31: Heart rate variability (HRV), alcohol, sleep, and more
In this “Ask Me Anything” (AMA) episode, Peter and Bob first answer a variety of questions related to heart rate…
#184 – AMA #29: GLP-1 Agonists – The Future of Treating Obesity?
“Getting deeper into how this drug works has certainly made me appreciate its power.” —Peter Attia
Does fish oil cause cardiac arrhythmia in high-risk individuals?
Reports of increased risk of atrial fibrillation in high-risk patients taking fish oil
#182 – David Nutt: Psychedelics & Recreational Drugs
“It turns out that the drugs that have been most vilified and which we’ve been taught are the most dangerous, turned out to be the least dangerous.” —David Nutt
#181 – Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatment
“For a century we’ve been looking for magic bullets, but maybe all we need is a series of pretty good bullets.” —Bob Gatenby
#180 – AMA #28: All things testosterone and testosterone replacement therapy
“There were countless other studies to look at, but they all basically point in the same direction, which is testosterone replacement therapy improves lean mass, reduces fat mass, improves strength.” —Peter Attia