#143 – John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
“We need to defend our method. We need to defend our principles. We need to defend the honesty of science in trying to communicate it rather than building exaggerated promises or narratives that are not realistic.” —John Ioannidis
Teaching science through the lens of discovery
Like anyone with children right now, the end of this past school year went from in-person schooling to remote learning…
Time-restricted eating: efficacy versus effectiveness
What happens when people are prescribed a treatment vs what happens when people take the treatment are two different questions.
Randomized controlled trials: when the gold standard leaves you with fool’s gold
If I told you that I read a randomized double-blinded placebo-controlled trial conducted over 5 years and carried out in over 18,000 participants, is there any scenario under which you would not believe it to be an excellent trial?
Normative errors and Surgisphere
Last month, the New York Times profiled Dr. Sapan Desai, founder of Surgisphere, the company that supplied the data for two recently retracted studies.
The importance of red teams
“The first principle is that you must not fool yourself—and you are the easiest person to fool.” —Richard Feynman
Multiple problems with a study linking proximity to major roads to dementia, Parkinson’s disease, Alzheimer’s disease, and MS
“You miss 100% of the shots you don’t take.” —Wayne Gretzky
Qualy #109 – How does one select the right physician as a patient?
Today’s episode of The Qualys is from podcast #04 – AMA #1: alcohol, best lab tests, wearables, finding the right…
Nobel retractions
On January 2nd, Arnold made headlines after announcing she and her co-authors retracted a paper that was published in the prestigious journal Science in May of 2019, 7 months after winning the Nobel Prize.
Qualy #65 – The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test
Today’s episode of The Qualys is from podcast #32 – Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine,…