Category

Science of Aging

Learn more about the biology of aging, centenarians, rapamycin, mTOR, ‘anti-aging’ drugs, interventions that target the aging process, and more.

#281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D.

What we try to do is quite simple. We try to find drugs that will slow aging and extend mouse lifespan.” —Rich Miller

“Biological” clocks: a peek into the future or a haphazard guess of mortality?

Potential uses for the epigenetics of aging and why I don’t put much stock in epigenetics-based aging clocks at present

#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more

One of the most important things to understand when you are using some sort of intervention is, do you have a biomarker to know if you’re doing it correctly?” —Peter Attia

#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more

You can’t solve or even attempt to solve complicated problems if you aren’t asking the right questions and you don’t have the right frameworks.” —Peter Attia

A recent metformin study casts doubts on longevity indications

A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.

#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee

“I liken the human genome to a score of music, but a score is lifeless. There’s no music in a score, it’s just a code. You need a musician to bring it to life, and the cell is that musician.” —Sid Mukherjee

medical advice

When it comes to medical advice, is less always more?

To the general public, the trial-and-error process of science and medicine may erode confidence, but without it, we’d have no science and medicine at all.

#231 – AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more

“We have reached the limits of medicine 2.0 capacity, and if longevity is something we are aspiring for, we need a new strategy.” —Peter Attia

blood transfusions in humans

Modern Vampirism: “Young Blood” Transfusions

Blood from young mice has rejuvenating effects on old mice, but it’s too early to translate these results into treatments for humans.

Muscle Mass and Cognitive Function

A recent narrative review hypothesizes a key role for myokine disruption caused by physical inactivity.

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